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Blood, 1 August 2004, Vol. 104, No. 3, pp. 857-864. Prepublished online as a Blood First Edition Paper on April 8, 2004; DOI 10.1182/blood-2004-02-0414. This Article Full Text (PDF) All Versions of this Article: 2004-02-0414v1 104/3/857    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by de Lima, M. Articles by Andersson, B. S Search for Related Content PubMed PubMed Citation Articles by de Lima, M. Articles by Andersson, B. S Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 3, 2004 Accepted March 7, 2004 Once daily intravenous busulfan and fludarabine: clinical and pharmacokinetic results of a myeloablative, reduced toxicity conditioning regimen for allogeneic stem cell transplantation in AML and MDS Marcos de Lima*, Daniel Couriel, Peter F Thall, Xuemei Wang, Timothy Madden, Roy Jones, Elizabeth J Shpall, Munir Shahjahan, Betty Pierre, Sergio Giralt, Martin Korbling, James A Russell, Richard E Champlin, and Borje S Andersson U.T.M.D. Anderson Cancer Center, Houston, TX, USA Alberta Bone Marrow Transplant Program, Calgary, Alberta, Canada * Corresponding author; email: mdelima{at}mdanderson.org. Postulating favorable antileukemic effect with improved safety, we used intravenous busulfan and fludarabine as conditioning therapy for allogeneic hematopoietic stem cell transplantation (HSCT) for AML and myelodysplastic syndrome (MDS). Fludarabine 40mg/m2 and intravenous busulfan 130mg/m2 were given once daily for 4 days, with tacrolimus-methotrexate as graft-versus-host disease (GVHD) prophylaxis. We treated 74 AML and 22 MDS patients, with a median age of 45 years (range, 19-66). Only 20% of the patients were in first complete remission (CR) at transplant. Donors were HLA-compatible related (n= 60) or matched-unrelated (n=36). The CR rate for 54 patients with active disease was 85%. At a median follow-up of 12 months, one-year regimen-related and treatment-related mortalities were 1% and 3%, respectively. Two patients had reversible hepatic veno-occlusive-disease. Actuarial one-year overall (OS) and event-free survival (EFS) were 65% and 52% for all patients, and 81% and 75% for patients transplanted in CR. Recipient age and donor type did not influence OS or EFS. Median busulfan clearance was 109 ml/min/m2 and median daily area-under-the-plasma-concentration-versus-time-curve was 4,871 µMol-min, with negligible inter-dose variability in pharmacokinetic parameters. The results suggest that intravenous busulfan-fludarabine is an efficacious, reduced-toxicity, myeloablative-conditioning regimen for AML and MDS patients undergoing HSCT. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Fludarabine finds its significant other? John Barrett Blood 2004 104: 603-604. [Full Text] [PDF] This article has been cited by other articles: S. Parmar, M. del Lima, Y. Zou, P. A. Patah, P. Liu, P. Cano, G. Rondon, S. Pesoa, L. de Padua Silva, M. H. Qazilbash, et al. 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Schleuning, R. Schwerdtfeger, B. Hertenstein, E. Mischak-Weissinger, D. Bunjes, S. v. Harsdorf, C. Scheid, U. Holtick, H. Greinix, et al. Long-term survival in refractory acute myeloid leukemia after sequential treatment with chemotherapy and reduced-intensity conditioning for allogeneic stem cell transplantation Blood, August 1, 2006; 108(3): 1092 - 1099. [Abstract] [Full Text] [PDF] S.-W. Kim, T. E. Tanimoto, N. Hirabayashi, S. Goto, M. Kami, S. Yoshioka, T. Uchida, K. Kishi, Y. Tanaka, A. Kohno, et al. Myeloablative allogeneic hematopoietic stem cell transplantation for non-Hodgkin lymphoma: a nationwide survey in Japan Blood, July 1, 2006; 108(1): 382 - 389. [Abstract] [Full Text] [PDF] S. Tauro, C. Craddock, K. Peggs, G. Begum, P. Mahendra, G. Cook, J. Marsh, D. Milligan, A. Goldstone, A. Hunter, et al. 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