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Blood, 15 September 2004, Vol. 104, No. 6, pp. 1808-1815. Prepublished online as a Blood First Edition Paper on May 27, 2004; DOI 10.1182/blood-2004-02-0426. This Article Full Text (PDF) Supplemental Figures All Versions of this Article: 2004-02-0426v1 104/6/1808    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Schlecht, G. Articles by Dadaglio, G. Search for Related Content PubMed PubMed Citation Articles by Schlecht, G. Articles by Dadaglio, G. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 3, 2004 Accepted May 3, 2004 Murine plasmacytoid Dendritic Cells Induce Effector/Memory CD8+ T cell Responses in vivo after Viral Stimulation Geraldine Schlecht, Sylvie Garcia, Nicolas Escriou, Antonio A Freitas, Claude Leclerc, and Gilles Dadaglio* Biologie des Regulations Immunitaires, Institut Pasteur, Paris, France Biologie des Populations Lymphocytaires, Institut Pasteur, Paris, France Genetique Moleculaire des Virus Respiratoires, Institut Pasteur, Paris, France * Corresponding author; email: gdadag{at}pasteur.fr. Like their human counterparts, mouse plasmacytoid dendritic cells (pDCs) play a central role in innate immunity against viral infections, but their capacity to prime T cells in vivo remains unknown. We show here that virus-activated pDCs differentiate into antigen-presenting cells able to induce effector/memory CD8+ T cell responses in vivo against both epitopic peptides and endogenous antigen, whereas pDCs activated by synthetic oligodeoxynucleotides containing unmethylated cytosine-guanine motifs (CpG) acquire only the ability to recall antigen-experienced T cell responses. We also show that immature pDCs are unable to induce effector or regulatory CD8+ T cell responses. Thus, murine pDCs take part in both innate and adaptive immune responses by directly priming naive CD8+ T cells during viral infection. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Plasmacytoid dendritic cell: vive le dilettante! Marco Colonna Blood 2004 104: 1596-1597. [Full Text] [PDF] This article has been cited by other articles: J. McGill, J. W. Heusel, and K. L. 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