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Blood, 1 August 2004, Vol. 104, No. 3, pp. 829-831. Prepublished online as a Blood First Edition Paper on April 15, 2004; DOI 10.1182/blood-2004-02-0477. This Article Full Text (PDF) All Versions of this Article: 2004-02-0477v1 104/3/829    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Coriu, D. Articles by Solomon, A. Search for Related Content PubMed PubMed Citation Articles by Coriu, D. Articles by Solomon, A. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 6, 2004 Accepted March 26, 2004 A molecular basis for nonsecretory myeloma Daniel Coriu, Kristal Weaver, Maria Schell, Manfred Eulitz, Charles L Murphy, Deborah T Weiss, and Alan Solomon* Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN, USA; Department of Hematology, University of Medicine 'Carol Davila', Bucharest, Romania Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN, USA Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN, USA; GSF Institute of Molecular Immunology, Munich, Germany * Corresponding author; email: asolomon{at}mc.utmck.edu. The biosynthesis of aberrant Ig polypeptides by monoclonal plasma cells has been implicated in the pathogenesis of nonsecretory myeloma. Our studies of a patient with this disorder indeed have demonstrated the presence of abnormal -light chains that resulted from a frameshift mutation in nucleotides encoding the constant region of the molecule. As a consequence of a 2-base deletion in codon 187 and loss of the normal stop codon, this portion of the -chain was composed of 128 amino acids (rather than the expected 106), with a completely anomalous sequence after position 187 that included absence of the cysteines required for intra- and inter-chain disulfide bonds. The unusual primary structure of this component was confirmed by mass spectrometric and amino acid sequence analyses of cytoplasmic protein extracts. Our studies provide the first evidence that human nonsecretory myeloma may result from an alteration in the light chain constant region. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Constipated myeloma P. Leif Bergsagel Blood 2004 104: 602. [Full Text] [PDF] This article has been cited by other articles: R PRASAD, R R YADAV, A SINGH, S P MATHUR, Y MANGAL, and M SINGH Non-secretory multiple myeloma presenting with diffuse sclerosis of affected bones interspersed with osteolytic lesions Br. J. Radiol., February 1, 2009; 82(974): e29 - e31. [Abstract] [Full Text] [PDF]

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