|
|
Blood, 15 September 2004, Vol. 104, No. 6, pp. 1894-1897.
Prepublished online as a Blood First Edition Paper on April 29, 2004; DOI 10.1182/blood-2004-02-0508.
 Previous Article | Next Article 
Submitted February 9, 2004
Accepted April 12, 2004
Risk Factors for Syngeneic Graft-versus-Host Disease After Adult Hematopoietic Cell Transplantation
Kristina M Adams*, Leona A Holmberg, Wendy Leisenring, Alexander Fefer, Katherine A Guthrie, Tracy S Tylee, George B McDonald, William I Bensinger, and J L Nelson
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Obstetrics & Gynecology, University of Washington, Seattle, WA, USA
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Division of Medical Oncology, University of Washington, Seattle, WA, USA
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
School of Medicine, University of Washington, Seattle, WA, USA
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Division of Gastroenterology, University of Washington, Seattle, WA, USA
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Division of Rheumatology, University of Washington, Seattle, WA, USA
* Corresponding author; email: adamsk{at}u.washington.edu.
Syngeneic graft-versus-host disease (sGVHD) has been described after hematopoietic cell transplantation (HCT), but remains poorly defined. We retrospectively reviewed adult syngeneic HCT at our center (1980-2002) for sGVHD to investigate incidence, morbidity, and risk factors with a primary focus on parity. Among 119 transplants, there were 21 cases of biopsy-proven sGVHD. The cumulative incidence was 18% with multi-organ involvement in 6 cases and one death. sGVHD was more frequent when the donor was parous (32%) than nulliparous (9%) or male (13%; p=0.03) and when the recipient was parous (31%) than nulliparous (7%) or male (13%; p=0.02). Other univariable risk factors included older age (p<0.01), busulfan/melphalan/thiotepa conditioning (p<0.01), interleukin-2 (p=0.02), HLA-A26 (p=0.03), and more recent transplant year (p<0.01). Overall, risk factors were similar to those described in GVHD. Although an independent effect of parity could not be completely separated from other factors, donor and recipient pregnancy history merits further investigation.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
L. Fouillard, M. Labopin, A. Gratwohl, E. Gluckman, F. Frassoni, D. W. Beelen, R. Willemze, E. Montserrat, D. Blaise, A. I. Atienza, et al.
Results of syngeneic hematopoietic stem cell transplantation for acute leukemia: risk factors for outcomes of adults transplanted in first complete remission
Haematologica,
June 1, 2008;
93(6):
834 - 841.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. C. Fung, M. A. Higman, and K. van Besien
Stem cell transplantation
ASH Self-Assessment Program,
January 1, 2007;
2007(1):
328 - 360.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. H. S. Tomas, F. R. Loberiza Jr, J. P. Klein, P. M. Layde, R. J. Lipchik, J. D. Rizzo, C. N. Bredeson, and M. M. Horowitz
Risk Factors for Bronchiolitis Obliterans in Allogeneic Hematopoietic Stem-Cell Transplantation for Leukemia
Chest,
July 1, 2005;
128(1):
153 - 161.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
