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Blood, 1 November 2004, Vol. 104, No. 9, pp. 2643-2645. Prepublished online as a Blood First Edition Paper on July 13, 2004; DOI 10.1182/blood-2004-02-0526. This Article Full Text (PDF) All Versions of this Article: 2004-02-0526v1 104/9/2643    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Wynn, R. F Articles by Bellantuono, I. Search for Related Content PubMed PubMed Citation Articles by Wynn, R. F Articles by Bellantuono, I. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 10, 2004 Accepted June 21, 2004 A small proportion of mesenchymal stem cells strongly express functionally active CXCR4 receptor capable of promoting migration to bone marrow Robert F Wynn, Claire A Hart, Carla Corradi-Perini, Liam O'Neill, Caroline A Evans, James E Wraith, Leslie J Fairbairn, and Ilaria Bellantuono* Stem Cell Research Group, Royal Manchester Children's Hospital, Manchester, United Kingdom Cancer Research UK Genito-Unrinary Group, Paterson Institute for Cancer Research, Manchester, United Kingdom Haematology, 5LRF Proteomics Facility, Manchester, United Kingdom Willink Biochemical Genetic Unit, Royal Manchester Children's Hospital, Manchester, United Kingdom Cancer Research UK Gene Therapy Group, Paterson Institute for Cancer Research, Manchester, United Kingdom * Corresponding author; email: ilaria.bellantuono{at}cmmc.nhs.uk. Homing of bone marrow stromal cells (MSC) to bone/ bone marrow post transplantation, important for the correction of conditions such as metabolic storage disorders, can occur but with poor efficiency. Substantial improvements in engraftment will be required in order to derive a clinical benefit from MSC transplantation. Chemokines are the most important factors controlling cellular migration. Stromal Derived Factor-1 (SDF-1) has been shown to be critical in promoting the migration of cells to the bone marrow, via its specific receptor CXCR4. The aim of our study was to investigate CXCR4 expression on MSC and its role in mediating migration to bone marrow. We show that CXCR4, although present at the surface of a small subset of MSC, is important for mediating specific migration of these cells to bone marrow. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Morito, T. Muneta, K. Hara, Y.-J. Ju, T. 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