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Blood, 15 July 2004, Vol. 104, No. 2, pp. 550-557. Prepublished online as a Blood First Edition Paper on March 30, 2004; DOI 10.1182/blood-2004-02-0566. This Article Full Text (PDF) All Versions of this Article: 2004-02-0566v1 104/2/550    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rombouts, E. J Articles by Ploemacher, R. E Search for Related Content PubMed PubMed Citation Articles by Rombouts, E. J Articles by Ploemacher, R. E Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 17, 2004 Accepted March 17, 2004 Relation between CXCR-4 expression, Flt3 mutations and unfavourable prognosis of adult acute myeloid leukemia Elwin J Rombouts*, Biljana Pavic, Bob Lowenberg, and Rob E Ploemacher Hematology, ErasmusMC, Rotterdam, The Netherlands * Corresponding author; email: w.rombouts{at}erasmusmc.nl. Recently it was shown that, analogous to normal hematopoietic cells, the level of CXCR-4 expression on AML cells correlates with SDF-1 induced chemotaxis. As we speculated that an anomalous organ distribution of AML cells could affect cell survival and thus result in an altered fraction surviving chemotherapy, we examined a possible correlation between patient prognosis and CXCR-4 expression in AML patients. We found that patients with a high CXCR-4 expression in the CD34+ subset had a significantly reduced survival and a higher probability of relapse, resulting in a median RFS of only 8.3 months. CXCR-4 expression was significantly higher in Flt3/ITD AML than in Flt3/wt AML.Covariate analysis indicated that the prognostic significance of Flt3/ITDs with respect to RFS was no more apparent when analysed in conjunction with the expression of CXCR-4 in the CD34+ subset, suggesting that the poor prognosis of Flt3/ITD AML might be subordinate to the increased CXCR-4 expression. Using a G-CSF-R expressing 32D cell line we observed that SDF-1/CXCR4 interaction is required for the survival of myeloid differentiating cells and it also induces a block in G-CSF-induced myeloid differentiation. These data suggest that the SDF-1/CXCR-4 axis may influence therapy responsiveness and defines unfavourable prognosis in AML. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: CXCR-4: homing in on Flt3 Mark Levis Blood 2004 104: 303-304. [Full Text] [PDF] This article has been cited by other articles: R. Grundler, L. Brault, C. Gasser, A. N. Bullock, T. Dechow, S. Woetzel, V. Pogacic, A. Villa, S. Ehret, G. Berridge, et al. Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration J. Exp. Med., August 31, 2009; 206(9): 1957 - 1970. [Abstract] [Full Text] [PDF] S. W. Lane, D. T. Scadden, and D. G. Gilliland The leukemic stem cell niche: current concepts and therapeutic opportunities Blood, August 6, 2009; 114(6): 1150 - 1157. [Abstract] [Full Text] [PDF] Z. Zeng, Y. Xi Shi, I. J. Samudio, R.-Y. Wang, X. Ling, O. Frolova, M. Levis, J. B. Rubin, R. R. Negrin, E. H. Estey, et al. 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