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Blood, 1 November 2004, Vol. 104, No. 9, pp. 2675-2681. Prepublished online as a Blood First Edition Paper on July 1, 2004; DOI 10.1182/blood-2004-02-0567. This Article Full Text (PDF) All Versions of this Article: 2004-02-0567v1 104/9/2675    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Feugier, P. Articles by Andrieu, J.-M. Search for Related Content PubMed PubMed Citation Articles by Feugier, P. Articles by Andrieu, J.-M. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 13, 2004 Accepted June 17, 2004 Comparison of initial characteristics and long-term outcome of Lymphocyte-Predominant Hodgkin's Lymphoma and classical Hodgkin's Lymphoma patients at clinical stages IA and IIA prospectively treated by brief anthracycline-based chemotherapies plus extended high-dose irradiation Pierre Feugier, Eric Labouyrie, Malika Djeridane, Arash Jenabian, Viviane Dubruille, Christian Berthou, Christiane Ghandour, Bernard Desablens, Yasmine Chait, Philippe Casassus, Vincent Delwail, Norbert Ifrah, Annick Le Mevel, Thierry Lamy, Josette Briere, Pierre Colonna, and Jean-Marie Andrieu* Departement d'Hematologie, Hopital de Brabois, Nancy, France Departement de Cancerologie Medicale, Hopital Europeen Georges Pompidou, Paris, France Departement d'Hematologie, Hotel-Dieu, Nantes, France Departement d'Hematologie, Hopital Morvan, Brest, France Cabinet de Medecine Interne-Hematologie, Rennes, France Departement d'Hematologie, Hopital Sud, Amiens, France Departement d'Hematologie, Hopital Beaujon, Paris, France Departement d'Hematologie, Hopital Avicenne, Bobigny, France Departement d'Oncologie Hematologique et Therapie Cellulaire, Hopital La Miletrie, Poitiers, France Departement d'Hematologie, Centre Hospitalier et Universitaire, Angers, France Departement d'Hematologie, Centre Rene Gauducheau, Nantes, France Departement d'Hematologie, Centre Hospitalier et Universitaire, Rennes, France Departement d'Anatomie Pathologique, Hopital Saint-Louis, Paris, France * Corresponding author; email: cancero.egp{at}egp.ap-hop-paris.fr. Lymphocyte-Predominant Hodgkin's lymphoma (LPHL) according to the R.E.A.L. classification was considered on retrospective basis as a specific clinical entity with a large majority of patients at clinical stages (CS) IA or IIA. Out of the 500 CSIA-IIA Hodgkin's lymphoma (HL) patients prospectively treated between 1981 and 1996 by 1 or 3 courses of anthracycline-based chemotherapies combined with high dose extended irradiation, 42 were reclassified as LPHL. These 42 patients, none of whom had mediastinal involvement (MI), were compared with the 458 patients with classical HL (cHL), 144 without MI and 314 with MI. Surprisingly, male:female ratio, age, first site involved, hemoglobin level, lymphocyte count, sedimentation rate of patients with LPHL and cHL without MI were identical and significantly different from those of patients with cHL with MI. Moreover, 15-year HL mortality rates were similarly low in LPHL (2.4%) and cHL without MI patients (0.7%). Overall survival rates were also similar (86% and 82%) and as high as 100% and 95% in patients treated before the age of 40 years. This study demonstrated that LPHL and cHL without MI shared the same presenting characteristics and the same excellent long-term prognosis after a brief anthracycline-based chemotherapy plus high dose extended irradiation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. S. Abramson T-cell/histiocyte-rich B-cell lymphoma: biology, diagnosis, and management. Oncologist, April 1, 2006; 11(4): 384 - 392. [Abstract] [Full Text] [PDF] L. Nogova, T. Rudiger, and A. Engert Biology, Clinical Course and Management of Nodular Lymphocyte-Predominant Hodgkin Lymphoma Hematology, January 1, 2006; 2006(1): 266 - 272. [Abstract] [Full Text] [PDF] G. P. Canellos Chemotherapy Alone for Early Hodgkin's Lymphoma: An Emerging Option J. Clin. Oncol., July 20, 2005; 23(21): 4574 - 4576. [Full Text] [PDF]

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