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Blood, 15 March 2005, Vol. 105, No. 6, pp. 2400-2402. Prepublished online as a Blood First Edition Paper on November 30, 2004; DOI 10.1182/blood-2004-02-0612. This Article Full Text (PDF) Supplemental Videos All Versions of this Article: 2004-02-0612v1 105/6/2400    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Galimi, F. Articles by Gage, F. H Search for Related Content PubMed PubMed Citation Articles by Galimi, F. Articles by Gage, F. H Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 19, 2004 Accepted November 3, 2004 A role for bone marrow-derived cells in the vasculature of non-injured CNS Francesco Galimi, Robert G Summers, Henriette van Praag, Inder M Verma, and Fred H Gage* Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, USA; Dept. of Biomedical Sciences/INBB, University of Sassari Medical School, Sassari, Italy Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, USA * Corresponding author; email: gage{at}salk.edu. The contribution of hematopoietic cells to the formation of blood vessels is currently the focus of intense scrutiny. Bone marrow-derived endothelial progenitor cells are thought to generate endothelial cells in many tissues, including myocardium, muscle, and certain tumors. In the central nervous system, however, the possible role of bone marrow-derived angiocompetent cells remains unclear. Here we have investigated the long-term involvement of bone marrow-derived cells in the maintenance of endothelial structures in the brain, spinal cord, and retina. Using hematopoietic chimeras stably expressing GFP in bone marrow-derived tissues, we found large numbers of hematopoietic cells closely associated with vessels in the CNS. None of these cells, however, showed an endothelial phenotype. They were positive for monocytic and microglial surface markers and demonstrated active phagocytosis of neighboring endothelial elements. Bone marrow-derived, vasculature-associated cells in the non-injured adult CNS are distinct from endothelial cells, but play an active role in vascular structures. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. P.W. Rouhl, R. J. van Oostenbrugge, J. Damoiseaux, J.-W. C. Tervaert, and J. Lodder Endothelial Progenitor Cell Research in Stroke: A Potential Shift in Pathophysiological and Therapeutical Concepts Stroke, July 1, 2008; 39(7): 2158 - 2165. [Abstract] [Full Text] [PDF] C Boettcher, E Ulbricht, D Helmlinger, A F Mack, A Reichenbach, P Wiedemann, H-J Wagner, M W Seeliger, A Bringmann, and J Priller Long-term engraftment of systemically transplanted, gene-modified bone marrow-derived cells in the adult mouse retina Br J Ophthalmol, February 1, 2008; 92(2): 272 - 275. [Abstract] [Full Text] [PDF] K. Gertz, J. Priller, G. Kronenberg, K. B. Fink, B. Winter, H. Schrock, S. Ji, M. Milosevic, C. Harms, M. Bohm, et al. Physical Activity Improves Long-Term Stroke Outcome via Endothelial Nitric Oxide Synthase-Dependent Augmentation of Neovascularization and Cerebral Blood Flow Circ. Res., November 10, 2006; 99(10): 1132 - 1140. [Abstract] [Full Text] [PDF] U. Ozerdem, K. Alitalo, P. Salven, and A. Li Contribution of Bone Marrow-Derived Pericyte Precursor Cells to Corneal Vasculogenesis Invest. Ophthalmol. Vis. Sci., October 1, 2005; 46(10): 3502 - 3506. [Abstract] [Full Text] [PDF]

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