SEARCH:   Advanced

Blood, 1 November 2004, Vol. 104, No. 9, pp. 2736-2738. Prepublished online as a Blood First Edition Paper on July 6, 2004; DOI 10.1182/blood-2004-02-0693. This Article Full Text (PDF) Supplemental Figure All Versions of this Article: 2004-02-0693v1 104/9/2736    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Parsons, C. H Articles by Kedes, D. H Search for Related Content PubMed PubMed Citation Articles by Parsons, C. H Articles by Kedes, D. H Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 24, 2004 Accepted June 21, 2004 Susceptibility of human fetal mesencyhmal stem cells to Kaposi's sarcoma-associated herpesvirus Christopher H Parsons, Barbara Szomju, and Dean H Kedes* Departments of Microbiology and Internal Medicine, University of Virginia, Charlottesville, VA, USA * Corresponding author; email: kedes{at}virginia.edu. Recent reports link Kaposi's sarcoma-associated herpesvirus (KSHV) infection of bone marrow cells to bone marrow failure and lymphoproliferative syndromes. The identity of the infected marrow cells, however, remains unclear. Other work has demonstrated that circulating mononuclear cells can harbor KSHV where its detection predicts the onset and severity of Kaposi's sarcoma. In either setting, bone marrow precursors may serve as viral reservoirs. Since mesenchymal stem cells (MSC) in human bone marrow regulate the differentiation and proliferation of adjacent hematopoietic precursors, we investigated their potential role in KSHV infection. Our results indicate that primary MSC are susceptible to both cell-free and cell-associated KSHV in culture. Moreover, infection persisted within nearly half of the cells for up to six weeks. Thus, MSC possess a clear capacity to support KSHV infection and warrant further exploration into their potential role in KSHV-related human disease. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: W. Wu, J. Vieira, N. Fiore, P. Banerjee, M. Sieburg, R. Rochford, W. Harrington Jr, and G. Feuer KSHV/HHV-8 infection of human hematopoietic progenitor (CD34+) cells: persistence of infection during hematopoiesis in vitro and in vivo Blood, July 1, 2006; 108(1): 141 - 151. [Abstract] [Full Text] [PDF]

	Blood Online is supported in part by Genentech BioOncology and Biogen Idec
	Copyright © 2004 by American Society of Hematology         Online ISSN: 1528-0020