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Blood, 1 October 2004, Vol. 104, No. 7, pp. 1923-1930. Prepublished online as a Blood First Edition Paper on June 10, 2004; DOI 10.1182/blood-2004-03-0803. This Article Full Text (PDF) All Versions of this Article: 2004-03-0803v1 104/7/1923    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Flomenberg, N. Articles by Weisdorf, D. Search for Related Content PubMed PubMed Citation Articles by Flomenberg, N. Articles by Weisdorf, D. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 3, 2004 Accepted May 15, 2004 Impact of HLA class I and class II high resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplant outcome Neal Flomenberg*, Lee Ann Baxter-Lowe, Dennis Confer, Marcelo Fernandez-Vina, Alexandra Filipovich, Mary Horowitz, Carolyn Hurley, Craig Kollman, Claudio Anasetti, Harriet Noreen, Ann Begovich, William Hildebrand, Effie Petersdorf, Barbara Schmeckpeper, Michelle Setterholm, Elizabeth Trachtenberg, Thomas Williams, Edmond Yunis, and Daniel Weisdorf Department of Medicine and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA Department of Surgery, University of California, San Francisco, CA, USA National Marrow Donor Program, Minneapolis, MN, USA Department of Oncology, Georgetown University, Washington, DC, USA Children's Hospital Medical Center, Cincinnati, OH, USA International Bone Marrow Transplant Registry, Medical College of Wisconsin, Milwaukee, WI, USA Georgetown University Medical Center, Washington, DC, USA Jaeb Center for Health Research, Tampa, FL, USA Blood & Marrow Transplant Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA Immunology/Histocompatibility Laboratory, Fairview-University Medical Center, Minneapolis, MN, USA Celera Diagnostics, Alameda, CA, USA University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA Fred Hutchinson Cancer Research Center, Seattle, WA, USA Summercrest Consulting, Columbia, MD, USA Children's Hospital Oakland Research Institute, Oakland, CA, USA Department of Pathology, University of New Mexico, Albuquerque, NM, USA Department of Cancer Immunology & AIDS, Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA, USA Adult Blood & Marrow Transplant Program, University of Minnesota, Minneapolis, MN, USA * Corresponding author; email: Neal.Flomenberg{at}mail.tju.edu. Outcome of unrelated donor marrow transplantation is influenced by donor-recipient matching for Human Leukocyte Antigens (HLA). Prior studies assessing the effects of mismatches at specific HLA loci have yielded conflicting results. The importance of high-resolution matching for all HLA loci has also not been established. We therefore examined the effects of HLA matching (low and/or high resolution) on engraftment, graft versus host disease (GVHD), and mortality in 1874 donor-recipient pairs retrospectively typed at high resolution for HLA-A, B, C, DRB1, DQ and DP. Mismatches at HLA-A, B, C and DRB1 each had similar adverse effects on mortality. Only HLA-A mismatches demonstrated significant adverse effects on GVHD. These adverse effects on outcome were more evident in transplants with low-resolution versus only high-resolution mismatches. Mismatches for HLA-DQ or DP did not significantly affect outcome. When high-resolution mismatches at HLA-A, B, C and DRB1 were considered together, adverse effects on survival and GVHD were observed. We therefore conclude that matching for HLA-C should be incorporated into algorithms for unrelated donor selection. High-resolution mismatches at HLA-A, B, C and DRB1 adversely impact outcome, but less so than low-resolution mismatches. When clinical circumstances allow, high-resolution class I typing may help optimize donor selection and improve outcome. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: HLA-C alleles can no longer be ignored in bone marrow donor selection Jon J. van Rood Blood 2004 104: 1912-1913. [Full Text] [PDF] This article has been cited by other articles: K. Sugimoto, M. Murata, S. Terakura, and T. Naoe CTL Clones Isolated from an HLA-Cw-Mismatched Bone Marrow Transplant Recipient with Acute Graft-Versus-Host Disease J. Immunol., November 1, 2009; 183(9): 5991 - 5998. [Abstract] [Full Text] [PDF] S. Parmar, M. del Lima, Y. Zou, P. A. Patah, P. Liu, P. Cano, G. Rondon, S. 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[Abstract] [Full Text] [PDF]

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