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Blood, 15 November 2004, Vol. 104, No. 10, pp. 3190-3197. Prepublished online as a Blood First Edition Paper on July 27, 2004; DOI 10.1182/blood-2004-03-0935. This Article Full Text (PDF) All Versions of this Article: 2004-03-0935v1 104/10/3190    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chou, J. Articles by Furie, B. Search for Related Content PubMed PubMed Citation Articles by Chou, J. Articles by Furie, B. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 12, 2004 Accepted June 22, 2004 Hematopoietic Cell-Derived Microparticle Tissue Factor Contributes to Fibrin Formation During Thrombus Propagation Janet Chou, Nigel Mackman, Glenn Merrill-Skoloff, Brian Pedersen, Barbara C Furie, and Bruce Furie* Center for Hemostasis and Thrombosis Research, Vascular Biology Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA Departments of Immunology and Cell Biology, The Scripps Research Institute, La Jolla, CA, USA * Corresponding author; email: bfurie{at}caregroup.harvard.edu. Tissue factor is expressed on non-vascular cells and cells within the vessel wall, and circulates in blood associated with microparticles. Although blood-borne tissue factor accumulates into the developing thrombus during thrombus formation, the contribution of blood borne tissue factor and vessel wall tissue factor to thrombin generation in vivo following vessel injury is unknown. To determine the source and role of blood borne microparticle- and vessel wall tissue factor, we studied arterial thrombus formation in a living mouse using intravital microscopy. Platelet, tissue factor and fibrin accumulation in the developing thrombus was compared in wildtype and low tissue factor mice. Compared to wildtype mice, low tissue factor mice formed very small platelet thrombi lacking tissue factor or fibrin. Wildtype and low TF mice were transplanted with bone marrow from wildtype and low TF mice. Arterial thrombi in low TF/wildtype chimeric mice had decreased size and decreased tissue factor and fibrin. Arterial thrombi in wildtype/low TF chimeric mice showed decreased platelet thrombus size but normal tissue factor and fibrin. 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