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Blood, 15 November 2004, Vol. 104, No. 10, pp. 3358-3360. Prepublished online as a Blood First Edition Paper on August 5, 2004; DOI 10.1182/blood-2004-03-1037. This Article Full Text (PDF) All Versions of this Article: 2004-03-1037v1 104/10/3358    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bonzheim, I. Articles by Rudiger, T. Search for Related Content PubMed PubMed Citation Articles by Bonzheim, I. Articles by Rudiger, T. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 19, 2004 Accepted May 26, 2004 Anaplastic Large Cell Lymphomas lack the expression of T-cell receptor molecules or molecules of proximal T-cell receptor signaling Irina Bonzheim, Eva Geissinger, Sabine Roth, Andreas Zettl, Alexander Marx, Andreas Rosenwald, Hans Konrad Muller-Hermelink, and Thomas Rudiger* Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany * Corresponding author; email: thomas.ruediger{at}mail.uni-wuerzburg.de. Anaplastic large cell lymphoma (ALCL) designates a heterogeneous group of CD30+ (systemic or primary cutaneous) peripheral T-cell lymphomas (PTCL). A subgroup of systemic ALCL is transformed by anaplastic lymphoma kinase (ALK). We compared 24 ALK+, 15 ALK- systemic and 7 cutaneous ALCL with 29 non-anaplastic PTCL in terms of T-cell receptor (TCR) rearrangements, expression of TCRs and TCR-associated molecules (CD3, ZAP-70). Despite their frequent clonal rearrangement for TCR, only 2/47 ALCL (4%) expressed TCR protein, while TCRs were detected on 27/29 non-anaplastic PTCL. Moreover, both TCR+ ALCL lacked CD3 and ZAP-70, i.e. molecules indispensable for the transduction of cognate TCR signals. Defective expression of TCRs is a common characteristic of all types of ALCL which may contribute to the dysregulation of intracellular signalling pathways controlling T-cell activation and survival. This molecular hallmark of ALCL is analogous to defective immunoglobulin expression distinguishing Hodgkin lymphoma from other B-cell lymphomas. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Ambrogio, C. Martinengo, C. Voena, F. Tondat, L. Riera, P. F. di Celle, G. Inghirami, and R. 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