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Blood, 15 January 2005, Vol. 105, No. 2, pp. 697-702. Prepublished online as a Blood First Edition Paper on September 7, 2004; DOI 10.1182/blood-2004-03-1059. This Article Full Text (PDF) All Versions of this Article: 2004-03-1059v1 105/2/697    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Feau, S. Articles by Ricciardi-Castagnoli, P. Search for Related Content PubMed PubMed Citation Articles by Feau, S. Articles by Ricciardi-Castagnoli, P. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 23, 2004 Accepted August 23, 2004 Dendritic cell-derived IL2 production is regulated by IL15 both in humans and mice Sonia Feau, Valeria Facchinetti, Francesca Granucci, Stefania Citterio, David Jarrossay, Samantha Seresini, Maria P Protti, Antonio Lanzavecchia, and Paola Ricciardi-Castagnoli* Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milan, Italy Laboratory of Tumor Immunology, Cancer Immunotherapy and Gene Therapy Program, Istituto Scientifico H San Raffaele, Milan, Italy Institute for Research in Biomedicine, Bellinzona, Switzerland * Corresponding author; email: paola.castagnoli{at}unimib.it. Dendritic cells (DCs) are involved in the initiation and regulation of innate and adaptive immune responses. Several molecular mechanisms regulate these diverse DC functions and we have previously reported that mouse dendritic cells (mDCs) can produce IL2, both in vitro and in vivo, in response to microbial activation and T-cell mediated stimuli. This property is shared by different DC subtypes, including Langerhans cells. Here we show that, upon appropriate stimulation, also human DCs, both plasmacytoid and myeloid subtypes, express IL2. Interestingly, production of IL2 by myeloid DCs is induced by T-cell mediated stimuli and depends on the presence of IL15. The key role of this cytokine in regulating IL2 production was also confirmed in the mouse system. In particular, we could show that IL15-deficient DCs were strongly impaired in the ability to produce IL2 following interaction with different microbial stimuli. Our results indicate that DC-produced IL2 is tightly co-regulated with the expression of IL15. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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