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Blood, 15 December 2004, Vol. 104, No. 13, pp. 3865-3871. Prepublished online as a Blood First Edition Paper on August 10, 2004; DOI 10.1182/blood-2004-03-1105. This Article Full Text (PDF) All Versions of this Article: 2004-03-1105v1 104/13/3865    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Morris, E. Articles by Mackinnon, S. Search for Related Content PubMed PubMed Citation Articles by Morris, E. Articles by Mackinnon, S. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 30, 2004 Accepted July 24, 2004 Outcome Following Alemtuzumab (CAMPATH-1H) -Containing Reduced Intensity Allogeneic Transplant Regimen for Relapsed and Refractory Non-Hodgkin's Lymphoma (NHL) Emma Morris*, Kirsty Thomson, Charles Craddock, Prem Mahendra, Donald Milligan, Gordon Cook, Graeme Murray Smith, Anne Parker, Steve Schey, Rajesh Chopra, Christopher Hatton, Jane Tighe, Anne Hunter, Karl Peggs, David Linch, Anthony Goldstone, and Stephen Mackinnon Department of Haematology, University College London Hospitals, London, United Kingdom; Department of Immunology, Imperial College, London, United Kingdom Department of Haematology, University College London Hospitals, London, United Kingdom UK Collaborative Group, London, United Kingdom * Corresponding author; email: emma.morris{at}ic.ac.uk. We report the outcome following RIT for NHL in 88 patients (LG-NHL n=41, HG-NHL n=37, MCL n=10). 37 had received prior autografts and 21 were in CR at transplant. Conditioning was with alemtuzumab, fludarabine and melphalan. Sixty-five patients received PBSC from HLA-identical siblings and 23 received BM from matched unrelated donors. GVHD prophylaxis was with cyclosporin A. Grade III-IV acute GVHD developed in 4 patients and chronic GVHD in 6 patients. With a median follow-up of 36 months (range 18-60), the actuarial overall survival (OS) at 3 years was 34% for HG-NHL, 60% for MCL and 73% for LG-NHL (p=<0.001). The 100-day and 3-year TRM for patients with LG-NHL were 2% and 11% respectively, and were better (p=0.01) than for patients with HG-NHL (27% and 38% respectively). The actuarial current progression free survival (PFS) at 3 years, including those who achieved remission following DLI for progression, was 65% for LG-NHL 50% for MCL and 34% for HG-NHL (p=0.002). 21 patients received DLI for MRD, persistent disease or relapse and 15 received DLI for mixed hematopoietic chimerism. Patients with relapsed LG-NHL and CLL achieve excellent PFS with extremely low TRM and GVHD, even when matched family donors are unavailable. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. E. Kohrt, B. B. Turnbull, K. Heydari, J. A. Shizuru, G. G. Laport, D. B. Miklos, L. J. Johnston, S. Arai, W.-K. Weng, R. T. Hoppe, et al. TLI and ATG conditioning with low risk of graft-versus-host disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donors Blood, July 30, 2009; 114(5): 1099 - 1109. [Abstract] [Full Text] [PDF] M. Foster, D. 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