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Blood, 1 December 2004, Vol. 104, No. 12, pp. 3598-3602. Prepublished online as a Blood First Edition Paper on August 17, 2004; DOI 10.1182/blood-2004-03-1107. This Article Full Text (PDF) All Versions of this Article: 2004-03-1107v1 104/12/3598    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by de Laat, H B Articles by de Groot, P. G Search for Related Content PubMed PubMed Citation Articles by de Laat, H B Articles by de Groot, P. G Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 23, 2004 Accepted June 14, 2004 2-glycoprotein I dependent lupus anticoagulant highly correlates with thrombosis in the Antiphospholipid Syndrome H B de Laat, Ronald H Derksen, Rolf T Urbanus, Mark Roest, and Philip G de Groot* Department of Haematology, University Medical Centre Utrecht, Utrecht, Utrecht, The Netherlands Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, Utrecht, The Netherlands Department of Clinical Chemistry, University Medical Centre Utrecht, Utrecht, Utrecht, The Netherlands * Corresponding author; email: ph.g.degroot{at}azu.nl. The antiphospholipid syndrome is characterized by the presence of antiphospholipid antibodies in plasma of patients with thrombo-embolic complications. A major problem in defining the syndrome is that serological assays to detect antiphospholipid antibodies have a low specificity. We recently published a method that specifically detects lupus anticoagulants (LAC) caused by anti-2-Glycoprotein I antibodies. Here we studied the clinical relevance of detecting 2-glycoprotein I-dependent LAC. Plasma samples were collected of 198 patients with autoimmune diseases. In those samples with a positive PTT-LA a modified aPTT based LAC test was performed with cardiolipin as confirming agent. 25/58 patients with LAC were dependent on the presence of anti-2-glycoprotein I antibodies. Presence of 2-glycoprotein I dependent LAC was almost completely associated with a history of thrombo-embolic complications (Odds Ratio 42.3, 95% confidence interval 194.3 - 9.9). An increased frequency of thrombosis was not found in 33 patients with LAC independent of anti-2-glycoprotein I antibodies (Odds Ratio 1.6, 95% confidence interval 3.9 - 0.8). The use of a LAC assay with cardiolipin as confirming agent strongly improves the detection of patients at risk for thrombosis. Our findings suggest that anti-2-glycoprotein I antibodies with LAC activity are antibodies that are responsible for the thrombo-embolic complications in APS. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A Tincani, M Filippini, M Scarsi, M Galli, and P. Meroni European attempts for the standardisation of the antiphospholipid antibodies Lupus, September 1, 2009; 18(10): 913 - 919. [Abstract] [PDF] A Tripodi Testing for lupus anticoagulants: all that a clinician should know Lupus, April 1, 2009; 18(4): 291 - 298. [Abstract] [PDF] B. Giannakopoulos, F. Passam, Y. Ioannou, and S. A. Krilis How we diagnose the antiphospholipid syndrome Blood, January 29, 2009; 113(5): 985 - 994. [Abstract] [Full Text] [PDF] Y. Shen, R Lee, E Frenkel, and R Sarode IgA antiphospholipid antibodies are an independent risk factor for thromboses Lupus, November 1, 2008; 17(11): 996 - 1003. [Abstract] [PDF] S. M. Nelson and I. 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