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Blood, 15 December 2004, Vol. 104, No. 13, pp. 4038-4045. Prepublished online as a Blood First Edition Paper on August 10, 2004; DOI 10.1182/blood-2004-03-1140. This Article Full Text (PDF) All Versions of this Article: 2004-03-1140v1 104/13/4038    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Herre, J. Articles by Brown, G. D Search for Related Content PubMed PubMed Citation Articles by Herre, J. Articles by Brown, G. D Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 25, 2004 Accepted July 26, 2004 Dectin-1 utilizes novel mechanisms for yeast phagocytosis in macrophages Jurgen Herre, Andrew S Marshall, Emmanuelle Caron, Alexander D Edwards, David L Williams, Edina Schweighoffer, Victor Tybulewicz, Caetano Reis e Sousa, Siamon Gordon, and Gordon D Brown* Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom Centre for Molecular Microbiology and Infection and Department of Biological Sciences, Imperial College, London, United Kingdom Immunobiology Laboratory, Cancer Research UK, London, United Kingdom Department of Surgery, James H. Quillen College of Medicine, Johnson City, USA National Institute for Medical Research, London, United Kingdom Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa * Corresponding author; email: gordon.brown{at}mweb.co.za. The phagocytosis of pathogens is a critical event in host defence, not only for clearance of the invading micro-organism, but also for the subsequent immune response. We have examined Dectin-1, a pro-inflammatory non-opsonic receptor for -glucans, and show that it mediates the internalisation of -glucan bearing ligands, including yeast particles. Although requiring tyrosine phosphorylation and the cytoplasmic ITAM-like motif, uptake mediated by Dectin-1 was different to any previously reported phagocytic receptor and was not dependent on Syk-kinase in macrophages. Furthermore, intracellular trafficking of this receptor was influenced by the nature of the -glucan ligand, which has significance for the biological activity of these immunomodulatory carbohydrates. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Dectin-1: unique appetite for yeast Cees van Kooten Blood 2004 104: 3846. [Full Text] [PDF] This article has been cited by other articles: E.-O. Glocker, A. Hennigs, M. Nabavi, A. A. Schaffer, C. Woellner, U. Salzer, D. Pfeifer, H. Veelken, K. Warnatz, F. Tahami, et al. A Homozygous CARD9 Mutation in a Family with Susceptibility to Fungal Infections N. Engl. J. Med., October 29, 2009; 361(18): 1727 - 1735. [Abstract] [Full Text] [PDF] S. Xu, J. Huo, M. Gunawan, I-H. Su, and K.-P. Lam Activated Dectin-1 Localizes to Lipid Raft Microdomains for Signaling and Activation of Phagocytosis and Cytokine Production in Dendritic Cells J. Biol. 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