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Blood, 15 December 2004, Vol. 104, No. 13, pp. 4142-4149. Prepublished online as a Blood First Edition Paper on August 24, 2004; DOI 10.1182/blood-2004-03-1190. This Article Full Text (PDF) All Versions of this Article: 2004-03-1190v1 104/13/4142    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Wysocka, M. Articles by Rook, A. Search for Related Content PubMed PubMed Citation Articles by Wysocka, M. Articles by Rook, A. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 30, 2004 Accepted August 11, 2004 Enhancement of the host immune responses in cutaneous T Cell lymphoma by CpG oligodeoxynucleotides and IL-15 Maria Wysocka*, Bernice M Benoit, Sarah Newton, Livio Azzoni, Luis J Montaner, and Alain Rook Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA The Wistar Institute, Philadelphia, PA, USA * Corresponding author; email: mwysocka{at}mail.med.upenn.edu. Patients with advanced cutaneous T cell lymphoma (CTCL) exhibit profound defects in cell-mediated immunity. Host immune functions appear to play an integral role in mediating disease-controlling responses in CTCL, therefore we investigated the effects of synthetic oligodeoxynucleotides with CpG motifs (CpG ODN), which have been recognized as immune stimulatory by virtue of activation of DCs following binding to Toll like receptor (TLR) 9. Peripheral blood mononuclear cells (PBMC) from patients with advanced CTCL (erythroderma with circulating malignant T cells) and normal volunteers were cultured with either CpG-A or CpG-B ODN. Patients' PBMC exhibited marked induction of IFN- release following culture with CpG-A. Similarly significant activation of NK cells and CD8 T cells occurred as assessed by up-modulation of CD69 expression and by natural killer lytic activity. Nevertheless, the PBMC of patients exhibited blunted responses to CpG-A compared to normal volunteers. In such cases, IL-15 was capable of producing levels of NK activation that were superior to CpG-A, while the combined effects of CpG-A plus IL-15 induced maximal activation of NK cells and further enhanced activation of CD8 T cells. These findings have important implications for the potential enhancement of anti-tumor immunity among patients with advanced CTCL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: P. Adam, B. Schmausser, M. Gobeler-Kolve, H. K. Muller-Hermelink, and M. Eck Gastric extranodal marginal zone B-cell lymphomas of MALT type exclusively express toll-like receptor 4 in contrast to other lymphomas infiltrating the stomach Ann. Onc., March 1, 2008; 19(3): 566 - 569. [Abstract] [Full Text] [PDF] R. B. Smeltz Profound Enhancement of the IL-12/IL-18 Pathway of IFN-{gamma} Secretion in Human CD8+ Memory T Cell Subsets via IL-15 J. Immunol., April 15, 2007; 178(8): 4786 - 4792. [Abstract] [Full Text] [PDF] T. A. Stoklasek, K. S. Schluns, and L. Lefrancois Combined IL-15/IL-15R{alpha} Immunotherapy Maximizes IL-15 Activity In Vivo J. Immunol., November 1, 2006; 177(9): 6072 - 6080. [Abstract] [Full Text] [PDF] S. T. Rosen and C. Querfeld Primary Cutaneous T-Cell Lymphomas Hematology, January 1, 2006; 2006(1): 323 - 330. [Abstract] [Full Text] [PDF] D. S. Goddard, K.-i. Yamanaka, T. S. Kupper, and D. A. Jones Activation of Neutrophils in Cutaneous T-Cell Lymphoma Clin. Cancer Res., December 1, 2005; 11(23): 8243 - 8249. [Abstract] [Full Text] [PDF]

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