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Blood, 1 November 2004, Vol. 104, No. 9, pp. 2933-2935. Prepublished online as a Blood First Edition Paper on July 6, 2004; DOI 10.1182/blood-2004-03-1209. This Article Full Text (PDF) All Versions of this Article: 2004-03-1209v1 104/9/2933    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Barrans, S. L Articles by Jack, A. S Search for Related Content PubMed PubMed Citation Articles by Barrans, S. L Articles by Jack, A. S Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 31, 2004 Accepted June 7, 2004 Strong Expression of FOXP1 Identifies a Distinct Subset of Diffuse Large B-Cell Lymphoma Patients with Poor Outcome Sharon L Barrans*, James A Fenton, Alison Banham, Roger G Owen, and Andrew S Jack HMDS, Academic Unit of Haematology and Oncology, Leeds General Infirmary, Leeds, United Kingdom Nuffield Department of Clinical Laboratory Sciences, LRF Immunodiagnostics Unit, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom * Corresponding author; email: sharonb{at}hmds.org.uk. FOXP1 (Forkhead box-P1) is a winged-helix transcription factor that is differentially expressed in resting and activated B cells. FOXP1 expression has been demonstrated in a subset of diffuse large B-cell lymphomas (DLBCL), and is more common in the non-germinal centre (GC), activated B-cell type; however its prognostic significance is uncertain. We have analysed presentation lymph nodes from 126 nodal DLBCLs, previously classified according to their GC and BCL2 status, for FOXP1 protein expression using standard immunocytochemistry. Uniform high FOXP1 expression was demonstrated in 23/126 cases of DLBCL. This high level of expression was almost exclusively confined to cases that lacked a GC phenotype, expressed MUM-1 and BCL2 in the absence of a t(14;18), and identified a group of patients with a particularly poor outcome within this already poor prognostic group. The data presented suggests that high FOXP1 expression is an independent prognostic factor in DLBCL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Copie-Bergman, P. Gaulard, K. Leroy, J. Briere, M. Baia, J.-P. Jais, G. A. Salles, F. Berger, C. Haioun, H. Tilly, et al. 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