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Blood, 1 December 2004, Vol. 104, No. 12, pp. 3821-3828. Prepublished online as a Blood First Edition Paper on July 27, 2004; DOI 10.1182/blood-2004-03-1212. This Article Full Text (PDF) All Versions of this Article: 2004-03-1212v1 104/12/3821    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ichinohe, T. Articles by Kodera, Y. Search for Related Content PubMed PubMed Citation Articles by Ichinohe, T. Articles by Kodera, Y. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 31, 2004 Accepted July 10, 2004 Feasibility of HLA-haploidentical hematopoietic stem-cell transplantation between non-inherited maternal antigen (NIMA)-mismatched family members linked with long-term feto-maternal microchimerism Tatsuo Ichinohe*, Takashi Uchiyama, Chihiro Shimazaki, Keitaro Matsuo, Shigehisa Tamaki, Masayuki Hino, Arata Watanabe, Motohiro Hamaguchi, Souichi Adachi, Hisashi Gondo, Nobuhiko Uoshima, Takao Yoshihara, Kazuo Hatanaka, Hiroshi Fujii, Keisei Kawa, Kazunobu Kawanishi, Koji Oka, Hideo Kimura, Mitsuru Itoh, Takeshi Inukai, Etsuko Maruya, Hiroh Saji, and Yoshihisa Kodera Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan Kyoto Prefectural University of Medicine, Kyoto, Japan Aichi Cancer Center Research Institute, Nagoya, Japan Yamada Red Cross Hospital, Misono, Japan Osaka City University Graduate School of Medicine, Osaka, Japan Nakadoori General Hospital, Akita, Japan Clinical Research Center, Nagoya Medical Center, Nagoya, Japan Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan Matsushita Memorial Hospital, Moriguchi, Japan Rinku General Medical Center, Izumisano, Japan Kyoto First Red Cross Hospital, Kyoto, Japan Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Japan Kinki University School of Medicine, Osaka-sayama, Japan Suzuka Kaisei Hospital, Suzuka, Japan Kita-Fukushima Medical Center, Date, Japan Kawasaki Medical School, Kurashiki, Japan University of Yamanashi School of Medicine, Tamaho, Japan NPO HLA Laboratory, Kyoto, Japan Bone Marrow Transplantation Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan * Corresponding author; email: nohe{at}kuhp.kyoto-u.ac.jp. Based on the hypothesis that long-term feto-maternal microchimerism is associated with acquired immunologic hyporesponsiveness to non-inherited maternal antigens (NIMA) or inherited paternal antigens (IPA), several groups have recently reported successful cases of non-T-cell-depleted hematopoietic stem-cell transplantation (SCT) from HLA-haploidentical family members mismatched for NIMA. In this study, we examined the outcomes of 35 patients with advanced hematologic malignancies who underwent HLA-2 or 3-antigen-incompatible SCT from a microchimeric NIMA-mismatched donor. After standard-intensity or reduced-intensity preparative regimens, all patients had sustained hematopoietic recovery with tacrolimus-based graft-versus-host disease (GVHD) prophylaxis. Grade II- IV acute GVHD occured in 19 of 34 evaluable patients (56%), while extensive chronic GVHD developed in 13 of 23 patients (57%) who could be evaluated. Multivariate analysis demonstrated that NIMA mismatch in the GVH direction was associated with a lower risk of severe grade III-IV acute GVHD when compared with IPA mismatch (P= .03). Fifteen patients were alive and 14 of them were disease-free with a median follow-up of 20 (range, 8-37) months. These results indicate that T-cell-replete SCT from an HLA-haploidentical NIMA-mismatched donor can offer durable remission with an acceptable risk of GVHD in selected patients with advanced hematologic malignancies who lack immediate access to a conventional stem-cell source. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Stern, L. Ruggeri, A. Mancusi, M. E. Bernardo, C. de Angelis, C. Bucher, F. Locatelli, F. Aversa, and A. Velardi Survival after T cell-depleted haploidentical stem cell transplantation is improved using the mother as donor Blood, October 1, 2008; 112(7): 2990 - 2995. 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