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Blood, 1 February 2005, Vol. 105, No. 3, pp. 1204-1213. Prepublished online as a Blood First Edition Paper on October 7, 2004; DOI 10.1182/blood-2004-03-1222. This Article Full Text (PDF) All Versions of this Article: 2004-03-1222v1 105/3/1204    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sasaki, H. Articles by Morishita, K. Search for Related Content PubMed PubMed Citation Articles by Sasaki, H. Articles by Morishita, K. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 5, 2004 Accepted August 6, 2004 Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia Hidenori Sasaki, Ichiro Nishikata, Toshiyuki Shiraga, Ena Akamatsu, Takeshi Fukami, Tomonori Hidaka, Yoko Kubuki, Akihiko Okayama, Kenji Hamada, Hisafumi Okabe, Yoshinori Murakami, Hirohito Tsubouchi, and Kazuhiro Morishita* Department of Biochemistry, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki, Japan; Second Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki, Japan Department of Biochemistry, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki, Japan Department of Biochemistry, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki, Japan; Miyazaki Prefecture Collaboration of Regional Entities for the Advancement of Technological Excellence, JST, Miyazaki, Japan Tumor Suppression & Functional Genomics Project, National Cancer Center Research Institute, Tokyo, Japan Second Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki, Japan Department of Laboratory Medicine, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki, Japan 4th Dept. Pharmaceutical Res., Chugai Pharmaceutical Co., Ltd., Kanagawa, Japan * Corresponding author; email: kmorishi{at}med.miyazaki-u.ac.jp. Adult T-cell leukemia (ATL) caused by HTLV-1 infection, occurs in 2-4% of the HTLV-1 carriers with a long latent period, suggesting that additional alterations participate in the development of ATL. To characterize and identify novel markers of ATL, we examined the expression profiles of over 12,000 genes in 8 cases of acute-type ATL using microarray. One hundred and ninety-two genes containing with IL2 receptor , were upregulated more than 2-fold compared with CD4+ and CD4+CD45RO+T cells, and Tumor suppressor in lung cancer 1 (TSLC1), caveolin 1 and prostaglandin D2 synthase showed increased expression of more than 30-fold. TSLC1 is a cell adhesion molecule originally identified as a tumor suppressor in the lung but lacks its expression in normal or activated T cells. We confirmed ectopic expression of the TSLC1 in all acute-type ATL cells and in 7 of 10 ATL or HTLV-1-infected T cell lines. Introduction of TSLC1 into a human ATL cell line ED, enhanced both self-aggregation and adhesion ability to vascular endothelial cells. These results suggested that the ectopic expression of TSLC1 could provide a novel marker for acute-type ATL and may participate in tissue invasion, a characteristic feature of the malignant ATL cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. J. Hasstedt, I. D. Bezemer, P. W. Callas, C. Y. Vossen, W. Trotman, R. P. Hebbel, C. Demers, F. R. Rosendaal, and E. G. Bovill Cell adhesion molecule 1: a novel risk factor for venous thrombosis Blood, October 1, 2009; 114(14): 3084 - 3091. [Abstract] [Full Text] [PDF] C. A. Pise-Masison, M. Radonovich, K. Dohoney, J. C. Morris, D. O'Mahony, M.-J. Lee, J. Trepel, T. A. Waldmann, J. E. Janik, and J. N. Brady Gene expression profiling of ATL patients: compilation of disease-related genes and evidence for TCF4 involvement in BIRC5 gene expression and cell viability Blood, April 23, 2009; 113(17): 4016 - 4026. [Abstract] [Full Text] [PDF] M. Z. Dewan, N. Takamatsu, T. Hidaka, K. Hatakeyama, S. Nakahata, J.-i. Fujisawa, H. Katano, N. Yamamoto, and K. Morishita Critical Role for TSLC1 Expression in the Growth and Organ Infiltration of Adult T-Cell Leukemia Cells In Vivo J. Virol., December 1, 2008; 82(23): 11958 - 11963. [Abstract] [Full Text] [PDF] T. Hidaka, S. Nakahata, K. Hatakeyama, M. Hamasaki, K. Yamashita, T. Kohno, Y. Arai, T. Taki, K. Nishida, A. Okayama, et al. Down-regulation of TCF8 is involved in the leukemogenesis of adult T-cell leukemia/lymphoma Blood, July 15, 2008; 112(2): 383 - 393. [Abstract] [Full Text] [PDF] M. Baba, M. Okamoto, T. Hamasaki, S. Horai, X. Wang, Y. Ito, Y. Suda, and N. 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