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Blood, 15 September 2004, Vol. 104, No. 6, pp. 1606-1615. Prepublished online as a Blood First Edition Paper on June 17, 2004; DOI 10.1182/blood-2004-04-1257. This Article Full Text (PDF) All Versions of this Article: 2004-04-1257v1 104/6/1606    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Shattil, S. J Articles by Newman, P. J Search for Related Content PubMed PubMed Citation Articles by Shattil, S. J Articles by Newman, P. J Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 5, 2004 Accepted June 1, 2004 Integrins: Dynamic Scaffolds for Adhesion and Signaling in Platelets Sanford J Shattil* and Peter J Newman Cell Biology, The Scripps Research Institute, La Jolla, CA, USA Blood Research Institute, Blood Center of Southeastern Wisconsin, Milwaukee, WI, USA * Corresponding author; email: blood{at}scripps.edu. The major platelet integrin, IIb3, is required for platelet interactions with proteins in plasma and the extracellular matrix (ECM) that are essential for platelet adhesion and aggregation during hemostasis and arterial thrombosis. Ligand binding to IIb3 is controlled by inside-out signals that modulate receptor conformation and clustering. In turn, ligand binding triggers outside-in signals through IIb3 that, when disrupted, can cause a bleeding diathesis. In the past five years, there has been an explosion of knowledge about the structure and function of IIb3 and the related integrin, V3. These developments are discussed here and current models of bidirectional IIb3 signaling are presented as frameworks for future investigations. An understanding that IIb3 functions as a dynamic molecular scaffold for extracellular and intracellular proteins has translated into diagnostic and therapeutic insights relevant to hematology and cardiovascular medicine, and further advances can be anticipated. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Oki, K. Eto, K. Izawa, Y. Yamanishi, N. Inagaki, J. Frampton, T. Kitamura, and J. Kitaura Evidence That Integrin {alpha}IIb{beta}3-dependent Interaction of Mast Cells with Fibrinogen Exacerbates Chronic Inflammation J. Biol. Chem., November 6, 2009; 284(45): 31463 - 31472. [Abstract] [Full Text] [PDF] K. 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