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Blood, 1 December 2004, Vol. 104, No. 12, pp. 3507-3512. Prepublished online as a Blood First Edition Paper on August 17, 2004; DOI 10.1182/blood-2004-04-1389. This Article Full Text (PDF) All Versions of this Article: 2004-04-1389v1 104/12/3507    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Towatari, M. Articles by Ohno, R. Search for Related Content PubMed PubMed Citation Articles by Towatari, M. Articles by Ohno, R. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 12, 2004 Accepted July 9, 2004 Combination of intensive chemotherapy and imatinib can rapidly induce high-quality complete remission for a majority of patients with newly diagnosed BCR-ABL positive acute lymphoblastic leukemia Masayuki Towatari, Masamitsu Yanada*, Noriko Usui, Jin Takeuchi, Isamu Sugiura, Makoto Takeuchi, Fumiharu Yagasaki, Yasukazu Kawai, Shuichi Miyawaki, Shigeki Ohtake, Itsuro Jinnai, Keitaro Matsuo, Tomoki Naoe, and Ryuzo Ohno Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan Jikei University School of Medicine, Tokyo, Japan Nihon University School of Medicine, Tokyo, Japan Toyohashi Municipal Hospital, Toyohashi, Japan Minami-Okayama Medical Center, Okayama, Japan Saitama Medical School, Saitama, Japan Faculty of Medical Sciences, University of Fukui, Fukui, Japan Saiseikai Maebashi Hospital, Maebashi, Japan Kanazawa University School of Health Sciences, Kanazawa, Japan Aichi Cancer Center, Nagoya, Japan * Corresponding author; email: myanada{at}med.nagoya-u.ac.jp. The outcome for adult patients with BCR-ABL positive acute lymphoblastic leukemia (ALL) remains dismal and long-term survival can hardly be achieved except by allogeneic hematopoietic stem cell transplantation (HSCT). The Japan Adult Leukemia Study Group (JALSG) has recently started a phase 2 trial with intensive chemotherapy and imatinib for newly diagnosed BCR-ABL positive ALL patients, and we present here the interim results for the first 24 patients. All patients except one case of early death (96%) attained complete remission (CR) after a single course of remission induction therapy. PCR negativity was achieved in 28% of the patients on day 28, in 50% on day 63, and in up to 78% during the follow-up period. The toxicity profile was almost similar to that with chemotherapy alone. As a result, 15 patients (63%) could receive allogeneic HSCT during their first CR. Although the number of patients is small and the observation period is too short, the combination therapy is very promising and produces high-quality CR for a majority of newly diagnosed patients with BCR-ABL positive ALL. This is especially useful because it provides the patients with a better chance to receive allogeneic HSCT. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. R. Schultz, W. P. Bowman, A. Aledo, W. B. Slayton, H. Sather, M. Devidas, C. Wang, S. M. Davies, P. S. Gaynon, M. Trigg, et al. Improved Early Event-Free Survival With Imatinib in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Children's Oncology Group Study J. Clin. Oncol., November 1, 2009; 27(31): 5175 - 5181. [Abstract] [Full Text] [PDF] F. Castagnetti, F. Palandri, M. Amabile, N. Testoni, S. Luatti, S. Soverini, I. Iacobucci, M. Breccia, G. Rege Cambrin, F. Stagno, et al. 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