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Blood, 1 December 2004, Vol. 104, No. 12, pp. 3527-3534. Prepublished online as a Blood First Edition Paper on August 5, 2004; DOI 10.1182/blood-2004-04-1390. This Article Full Text (PDF) All Versions of this Article: 2004-04-1390v1 104/12/3527    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kosaka, Y. Articles by Ishii, E. Search for Related Content PubMed PubMed Citation Articles by Kosaka, Y. Articles by Ishii, E. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 12, 2004 Accepted July 22, 2004 Infant acute lymphoblastic leukemia with MLL gene rearrangements: outcome following intensive chemotherapy and hematopoietic stem cell transplantation Yoshiyuki Kosaka, Katsuyoshi Koh, Naoko Kinukawa, Yoshihiro Wakazono, Keiichi Isoyama, Takanori Oda, Yasuhide Hayashi, Shigeru Ohta, Hiroshi Moritake, Megumi Oda, Yoshihisa Nagatoshi, Hisato Kigasawa, Yasushi Ishida, Akira Ohara, Ryouji Hanada, Masahiro Sako, Takeyuki Sato, Shuki Mizutani, Keizo Horibe, and Eiichi Ishii* Department of Hematology and Oncology, Hyogo Children's Hospital, Kobe, Hyogo, Japan Department of Pediatrics, University of Tokyo, Tokyo, Japan Department of Medical Information Science, Kyushu University, Fukuoka, Japan Division of Pediatrics, Kyoto Katsura Hospital, Kyoto, Japan Department of Pediatrics, Showa University Fujigaoka Hospital, Yokohama, Kanagawa, Japan Department of Pediatrics, Hokkaido Children's Hospital and Medical Center, Sapporo, Hokkaido, Japan Department of Hematology and Oncology, Gunma Children's Medical Center, Kitatachibana, Gunma, Japan Department of Pediatrics, Shiga Medical School, Ohtsu, Shiga, Japan Department of Pediatrics, University of Miyazaki, Miyazaki, Japan Department of Pediatrics, Okayama University, Okayama, Japan Section of Pediatrics, National Kyushu Cancer Center, Fukuoka, Japan Department of Hematology, Kanagawa Children's Medical Center, Yokohama, Kanagawa, Japan Department of Pediatrics, Ehime University, Shigenobumachi, Ehime, Japan Department of Pediatrics, Toho University, Tokyo, Japan Department of Hematology and Oncology, Saitama Children's Medical Center, Saitama, Japan Department of Pediatrics, Osaka City General Hospital, Osaka, Japan Department of Pediatrics, Chiba University, Chiba, Japan Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan Clinical Research Center, National Nagoya Hospital, Nagoya, Aichi, Japan Department of Pediatrics, Saga University, Saga, Japan * Corresponding author; email: ishiei{at}med.saga-u.ac.jp. Forty-four infants with acute lymphoblastic leukemia (ALL) characterized by MLL gene rearrangements were treated on a protocol of intensive chemotherapy followed by hematopoietic stem cell transplantation (HSCT) between November 1998 and June 2002. The remission induction rate was 91.0%, while the 3-year overall survival and event-free survival (EFS) rates, with 95% confidence intervals, were 58.2% (43.5-72.9%) and 43.6% (28.5-58.7%), respectively. Univariate analysis of EFS by presenting features indicated a poorer outcome in patients younger than 6 months of age with high white blood cell counts (100 x 109/L) (EFS rate, 9.4% vs. 55.1% for all others, P=0.0036) and in those with central nervous system invasion (EFS rate, 10.0% vs. 56.9% for all others, P=0.0073). The 3-year post-transplant EFS rate for the 29 patients who underwent HSCT in first remission was 64.4% (46.4-82.4%). In this subgroup, only the timing of HSCT (first remission vs. others) proved to be a significant risk factor by multivariate analysis (P<0.0001). These results suggest that early introduction of HSCT, possibly with a less toxic conditioning regimen, may improve the prognosis for infants with MLL-positive ALL. Identification of subgroups who respond well to intensified chemotherapy alone should have a high priority in future investigations. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. K. Slany The molecular biology of mixed lineage leukemia Haematologica, July 1, 2009; 94(7): 984 - 993. [Abstract] [Full Text] [PDF] Y. Furuichi, K. Goi, T. Inukai, H. Sato, A. Nemoto, K. Takahashi, K. Akahane, K. Hirose, H. Honna, I. Kuroda, et al. 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