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Blood, 15 June 2005, Vol. 105, No. 12, pp. 4800-4806. Prepublished online as a Blood First Edition Paper on February 10, 2005; DOI 10.1182/blood-2004-04-1406. This Article Full Text (PDF) All Versions of this Article: 2004-04-1406v1 105/12/4800    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Belanger, S. D Articles by St-Pierre, Y. Search for Related Content PubMed PubMed Citation Articles by Belanger, S. D Articles by St-Pierre, Y. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 13, 2004 Accepted February 4, 2005 Role of selectins in the triggering, growth, and dissemination of T lymphoma cells; implication of L-selectin in the growth of thymic lymphoma Simon D Belanger and Yves St-Pierre* INRS-Institut Armand-Frappier, Universite du Quebec, Laval, QC, Canada * Corresponding author; email: yves.st-pierre{at}inrs-iaf.uquebec.ca. We previously showed that ICAM-1 expression by the host was essential for lymphoma dissemination. Since selectins usually act in a coordinated fashion with ICAM-1 in the recruitment of circulating normal cells, we investigated their implication in lymphomagenesis and metastasis. Using selectin-deficient mice, we found that while the absence of E-, P-, or L-selectins did not affect the triggering of radiation-induced thymic lymphoma, absence of L-selectin on lymphoma cells reduced their capacity to grow in the thymus. This defect, however, was overcome by altering the integrity of the L-selectin-mediated interactions in the thymus, as shown in L-selectin deficient mice and by adoptive transfer experiments. We also found that lack of selectin expression by the host significantly delayed the dissemination of lymphomas to peripheral tissues. This resistance of selectin-deficient mice to lymphoma metastasis was dependent on the intrinsic properties of lymphoma cells as highly tumorigenic variants were insensitive to the absence of selectins. The observations that lymphoma cells disseminate with the same efficiency in both normal and selectin-deficient mice suggest that selectins, like ICAM-1, exert their influence at the post-homing stage of metastasis. These results provide definitive evidence that selectins play a significant role at different steps of T cell lymphoma development. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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