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Blood, 1 February 2005, Vol. 105, No. 3, pp. 1288-1294. Prepublished online as a Blood First Edition Paper on October 12, 2004; DOI 10.1182/blood-2004-04-1453. This Article Full Text (PDF) Supplemental Figure All Versions of this Article: 2004-04-1453v1 105/3/1288    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kang, S.-M. Articles by Russo, G. Search for Related Content PubMed PubMed Citation Articles by Kang, S.-M. Articles by Russo, G. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 16, 2004 Accepted September 20, 2004 Impaired T and B Cell Development in Tcl1 Deficient Mice Sang-Moo Kang, Maria Grazia Narducci, Cristina Lazzeri, Adriana M Mongiovi, Elisabetta Caprini, Antonella Bresin, Fabio Martelli, Jay Rothstein, Carlo M Croce, Max D Cooper, and Giandomenico Russo* University of Alabama at Birmingham and the Howard Hughes Medical Institute, Birmingham, AL, USA Istituto Dermopatico dell'Immacolata- Istituto di Ricovero e Cura a Carattere Scientifico, Roma, Italy Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA * Corresponding author; email: russo{at}idi.it. TCL1, the overexpression of which may result in T cell leukemia, is normally expressed in early embryonic tissues, the ovary and lymphoid lineage cells. Our analysis of mouse B lineage cells indicates that Tcl1 expression is initiated in pro-B cells and persists in splenic marginal zone and follicular B cells. T lineage Tcl1 expression begins in thymocyte progenitors, continues in CD4+CD8+ thymocytes, and is extinguished in mature T cells. In Tcl1 deficient mice, we found B lymphopoiesis to be compromised at the pre-B cell stage and T cell lymphopoiesis to be impaired at the CD4+CD8+ thymocyte stage. A corresponding increase was observed in thymocyte susceptibility to anti-CD3induced apoptosis. Reduced numbers of splenic follicular and germinal center B cells were accompanied by impaired production of IgG1 and IgG2b antibodies in response to a T-dependent antigen. The marginal zone B cells and T-cell independent antibody responses were also diminished in Tcl1-/- mice. This analysis indicates a significant role for Tcl1, a coactivator of Akt signaling, in normal T and B cell development and function. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. J. Tabrizi, H. Niiro, M. Masui, G. Yoshimoto, T. Iino, Y. Kikushige, T. Wakasaki, E. Baba, S. Shimoda, T. Miyamoto, et al. T Cell Leukemia/Lymphoma 1 and Galectin-1 Regulate Survival/Cell Death Pathways in Human Naive and IgM+ Memory B Cells through Altering Balances in Bcl-2 Family Proteins J. Immunol., February 1, 2009; 182(3): 1490 - 1499. [Abstract] [Full Text] [PDF] M. Herling, K. A. Patel, M. A. Teitell, M. Konopleva, F. Ravandi, R. Kobayashi, and D. Jones High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemia Blood, January 1, 2008; 111(1): 328 - 337. [Abstract] [Full Text] [PDF] G. Despouy, M. Joiner, E. Le Toriellec, R. Weil, and M. H. Stern The TCL1 oncoprotein inhibits activation-induced cell death by impairing PKC{theta} and ERK pathways Blood, December 15, 2007; 110(13): 4406 - 4416. [Abstract] [Full Text] [PDF] M. Noguchi, V. Ropars, C. Roumestand, and F. Suizu Proto-oncogene TCL1: more than just a coactivator for Akt FASEB J, August 1, 2007; 21(10): 2273 - 2284. [Abstract] [Full Text] [PDF] F.-S. Quan, C. Huang, R. W. Compans, and S.-M. Kang Virus-Like Particle Vaccine Induces Protective Immunity against Homologous and Heterologous Strains of Influenza Virus J. Virol., April 1, 2007; 81(7): 3514 - 3524. [Abstract] [Full Text] [PDF] I. Skountzou, F.-S. Quan, S. Gangadhara, L. Ye, A. Vzorov, P. Selvaraj, J. Jacob, R. W. Compans, and S.-M. Kang Incorporation of Glycosylphosphatidylinositol-Anchored Granulocyte- Macrophage Colony-Stimulating Factor or CD40 Ligand Enhances Immunogenicity of Chimeric Simian Immunodeficiency Virus-Like Particles J. Virol., February 1, 2007; 81(3): 1083 - 1094. [Abstract] [Full Text] [PDF] M. Hiromura, F. Suizu, M. Narita, K. Kinowaki, and M. Noguchi Identification of Nerve Growth Factor-responsive Element of the TCL1 Promoter as a Novel Negative Regulatory Element J. Biol. Chem., September 22, 2006; 281(38): 27753 - 27764. [Abstract] [Full Text] [PDF]

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