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Blood, 15 November 2004, Vol. 104, No. 10, pp. 3198-3204. Prepublished online as a Blood First Edition Paper on July 22, 2004; DOI 10.1182/blood-2004-04-1485. This Article Full Text (PDF) All Versions of this Article: 2004-04-1485v1 104/10/3198    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Uutela, M. Articles by Alitalo, K. Search for Related Content PubMed PubMed Citation Articles by Uutela, M. Articles by Alitalo, K. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 23, 2004 Accepted June 27, 2004 PDGF-D induces macrophage recruitment, increased interstitial pressure and blood vessel maturation during angiogenesis Marko Uutela, Maria Wirzenius, Karri Paavonen, Iiro Rajantie, Yulong He, Terhi Karpanen, Marja Lohela, Helge Wiig, Petri Salven, Katri Pajusola, Ulf Eriksson, and Kari Alitalo* University of Helsinki, Biomedicum Helsinki, Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Helsinki, Finland University of Bergen, Department of Biomedicine, Bergen, Norway Karolinska Institute, Ludwig Institute for Cancer Research, Stockholm, Sweden * Corresponding author; email: kari.alitalo{at}helsinki.fi. PDGF-D is a recently characterized member of the platelet-derived growth factor family with unknown in vivo functions. We investigated the effects of PDGF-D in transgenic mice by expressing it in basal epidermal cells followed by analysis of skin histology, interstitial fluid pressure and wound healing. When compared to control mice, the PDGF-D transgenic mice displayed increased numbers of macrophages and elevated interstitial fluid pressure in the dermis. Wound healing in the transgenic mice was characterized by increased density of cells and enhanced recruitment of macrophages. Macrophage recruitment was also the characteristic response when PDGF-D was expressed in skeletal muscle or ear via an adeno-associated virus vector. The combined expression of PDGF-D with vascular endothelial growth factor E (VEGF-E) led to increased pericyte/smooth muscle cell coating of the VEGF-E induced vessels and inhibition of the vascular leakiness that accompanies VEGF-E induced angiogenesis. These results show that full-length PDGF-D is activated in tissues and capable of increasing interstitial fluid pressure and macrophage recruitment, as well as the maturation of blood vessels in angiogenic processes. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Rangasamy, V. Misra, L. Zhen, C. G. Tankersley, R. M. Tuder, and S. Biswal Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression Am J Physiol Lung Cell Mol Physiol, June 1, 2009; 296(6): L888 - L900. [Abstract] [Full Text] [PDF] R. Tuuminen, A. I. Nykanen, R. Krebs, J. Soronen, K. Pajusola, M. A.I. Keranen, P. K. Koskinen, K. Alitalo, and K. B. Lemstrom PDGF-A, -C, and -D but not PDGF-B Increase TGF-{beta}1 and Chronic Rejection in Rat Cardiac Allografts Arterioscler Thromb Vasc Biol, May 1, 2009; 29(5): 691 - 698. 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