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Blood, 15 January 2005, Vol. 105, No. 2, pp. 874-878.
Prepublished online as a Blood First Edition Paper on September 23, 2004; DOI 10.1182/blood-2004-04-1532.
 Previous Article | Next Article 
Submitted April 26, 2004
Accepted August 14, 2004
Durable remissions with autologous stem cell transplantation for high risk HIV-associated lymphomas
Amrita Krishnan*, Arturo Molina, John Zaia, David Smith, Debbie Vasquez, Neil Kogut, Peter M Falk, Joseph Rosenthal, Joseph Alvarnas, and Stephen J Forman
Division of Hematology and Hematopoietic Stem Cell Transplantation, City of Hope Hematologic Neoplasia Program, City of Hope Cancer Center, Duarte, CA, USA
* Corresponding author; email: akrishnan{at}coh.org.
The treatment of HIV-associated lymphoma has changed since the widespread use of highly active antiretroviral therapy. HIV infected individuals can tolerate more intensive chemotherapy as they have better hematologic reserves and fewer infections. This has led to higher response rates in patients with HIV-associated Hodgkins (HD) or non-Hodgkin's lymphoma (NHL) treated with chemotherapy in conjunction with antiretroviral therapy. However, for patients with refractory or relapsed disease, salvage chemotherapy still offers little chance of long-term survival.
In the non-HIV setting, patients with relapsed HD or NHL have a better chance of long term remission with high dose chemotherapy with autologous stem cell rescue (ASCT) compared with conventional salvage chemotherapy. In a prior report we have demonstrated that this approach is well tolerated in patients with underlying immunodeficiency from HIV infection. Furthermore, similar engraftment to the non-HIV setting and low infectious risks have been observed. Herein, we expand upon this early experience with the largest single institution series of twenty patients. With long-term followup we demonstrate that ASCT can lead to an 85% progression free survival which suggests that this approach may be potentially curative in select patients with relapsed HIV associated HD or NHL.
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