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Blood, 1 January 2005, Vol. 105, No. 1, pp. 103-110. Prepublished online as a Blood First Edition Paper on September 14, 2004; DOI 10.1182/blood-2004-04-1570. This Article Full Text (PDF) All Versions of this Article: 2004-04-1570v1 105/1/103    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Savary, K. Articles by Gasc, J.-M. Search for Related Content PubMed PubMed Citation Articles by Savary, K. Articles by Gasc, J.-M. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 26, 2004 Accepted August 15, 2004 Role of the renin-angiotensin system in primitive erythropoiesis in the chick embryo Katia Savary, Annie Michaud, Judith Favier, Etienne Larger, Pierre Corvol, and Jean-Marie Gasc* College de France, INSERM, Unite 36, Paris, France * Corresponding author; email: jean-marie.gasc{at}college-de-france.fr. Inactivation of the gene encoding mouse angiotensin I-converting enzyme (ACE), which converts angiotensin I into angiotensin II, results in anemia in adult animals. This anemia is corrected by angiotensin II, demonstrating the involvement of angiotensin II in adult (definitive) erythropoiesis. We investigated the possible role of the renin-angiotensin system (RAS) in primitive erythropoiesis in the yolk sac of the chicken embryo. Enzymatically active ACE was detected in the yolk sac endoderm, concomitantly with the differentiation of blood islands in the adjacent yolk sac mesoderm. The simultaneous presence of all the other components of the RAS (renin, angiotensinogen, angiotensin II receptor) in the vicinity of the blood islands suggests that this system is involved in erythropoiesis. This role was confirmed by in vivo blockade of the RAS with fosinoprilate, a specific inhibitor of chicken ACE, which decreased hematocrit by 15%. A similar decrease in hematocrit was observed following treatment with the angiotensin II receptor antagonist Sar1-Ile8-Angiotensin II, suggesting that this effect was mediated by angiotensin II. Both treatments affected hematocrit by decreasing erythroblast proliferation. Thus, the RAS, and its effector peptide angiotensin II in particular, modulates primitive erythropoiesis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. S. Park and E. T. Zambidis A role for the renin-angiotensin system in hematopoiesis Haematologica, June 1, 2009; 94(6): 745 - 747. [Full Text] [PDF] E. T. Zambidis, T. Soon Park, W. Yu, A. Tam, M. Levine, X. Yuan, M. Pryzhkova, and B. Peault Expression of angiotensin-converting enzyme (CD143) identifies and regulates primitive hemangioblasts derived from human pluripotent stem cells Blood, November 1, 2008; 112(9): 3601 - 3614. [Abstract] [Full Text] [PDF] M. C. Yoder BB9 ACEs the HSC compartment Blood, April 15, 2008; 111(8): 3912 - 3912. [Full Text] [PDF] V. J. Jokubaitis, L. Sinka, R. Driessen, G. Whitty, D. N. Haylock, I. Bertoncello, I. Smith, B. Peault, M. Tavian, and P. J. Simmons Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues Blood, April 15, 2008; 111(8): 4055 - 4063. [Abstract] [Full Text] [PDF]

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