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Blood, 1 May 2005, Vol. 105, No. 9, pp. 3671-3678. Prepublished online as a Blood First Edition Paper on August 12, 2004; DOI 10.1182/blood-2004-04-1594. This Article Full Text (PDF) All Versions of this Article: 2004-04-1594v1 105/9/3671    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hoefnagel, J. J Articles by Vermeer, M. H Search for Related Content PubMed PubMed Citation Articles by Hoefnagel, J. J Articles by Vermeer, M. H Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 28, 2004 Accepted August 1, 2004 Distinct types of primary cutaneous large B-cell lymphoma identified by gene expression profiling Juliette J Hoefnagel, Remco Dijkman, Katia Basso, Patty M Jansen, Christian Hallermann, Rein Willemze*, Cornelis P Tensen, and Maarten H Vermeer Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands Institute for Cancer Genetics, Columbia University, New York, New York, USA Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands Department of Dermatology, University Hospital Goettingen, Goettingen, Germany * Corresponding author; email: willemze.dermatology{at}lumc.nl. In the EORTC classification two types of primary cutaneous large B-cell lymphoma (PCLBCL) are distinguished: primary cutaneous follicle center cell lymphomas (PCFCCL) and primary cutaneous large B-cell lymphomas of the leg (PCLBCL-leg). Distinction between both groups is considered important because of differences in prognosis (5-year survival >95% and 52%, respectively) and the first choice of treatment (radiotherapy or systemic chemotherapy, respectively), but is not generally accepted. To establish a molecular basis for this subdivision in the EORTC classification we investigated the gene expression profiles of 21 PCLBCL by oligonucleotide microarray analysis. Hierarchical clustering based on a B-cell signature (7450 genes) classified PCLBCL into two distinct subgroups consisting of respectively 8 PCFCCL and 13 PCLBCL-leg. PCLBCL-leg showed increased expression of genes associated with cell proliferation, the proto-oncogenes Pim-1, Pim-2 and c-Myc, and the transcription factors Mum1/IRF4 and Oct-2. In the group of PCFCCL high expression of SPINK2 was observed. Further analysis suggested that PCFCCL and PCLBCL-leg have expression profiles similar to that of germinal center B-cell-like and activated B-cell-like diffuse large B-cell lymphoma, respectively. The results of this study suggest that different pathogenetic mechanisms are involved in the development of PCFCCL and PCLBCL-leg and provide molecular support for the subdivision used in the EORTC classification. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Cutaneous lymphomas: it's location, location, location Elaine S. Jaffe Blood 2005 105: 3394-3395. [Full Text] [PDF] This article has been cited by other articles: F. Grange and F. 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Oncol., October 10, 2007; 25(29): 4684 - 4686. [Full Text] [PDF] F. Grange, M. Beylot-Barry, P. Courville, E. Maubec, M. Bagot, B. Vergier, P. Souteyrand, L. Machet, S. Dalac, E. Esteve, et al. Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type: Clinicopathologic Features and Prognostic Analysis in 60 Cases Arch Dermatol, September 1, 2007; 143(9): 1144 - 1150. [Abstract] [Full Text] [PDF] N. J. Senff, J. J. Hoefnagel, P. M. Jansen, M. H. Vermeer, J. van Baarlen, W. A. Blokx, M. R. Canninga-van Dijk, M.-L. Geerts, K. M. Hebeda, P. M. Kluin, et al. Reclassification of 300 Primary Cutaneous B-Cell Lymphomas According to the New WHO-EORTC Classification for Cutaneous Lymphomas: Comparison With Previous Classifications and Identification of Prognostic Markers J. Clin. Oncol., April 20, 2007; 25(12): 1581 - 1587. [Abstract] [Full Text] [PDF] L. Lamant, A. d. Reynies, M.-M. Duplantier, D. S. Rickman, F. Sabourdy, S. Giuriato, L. Brugieres, P. Gaulard, E. Espinos, and G. Delsol Gene-expression profiling of systemic anaplastic large-cell lymphoma reveals differences based on ALK status and two distinct morphologic ALK+ subtypes Blood, March 1, 2007; 109(5): 2156 - 2164. [Abstract] [Full Text] [PDF] R. Dijkman, R. van Doorn, K. Szuhai, R. Willemze, M. H. Vermeer, and C. P. Tensen Gene-expression profiling and array-based CGH classify CD4+CD56+ hematodermic neoplasm and cutaneous myelomonocytic leukemia as distinct disease entities Blood, February 15, 2007; 109(4): 1720 - 1727. [Abstract] [Full Text] [PDF] L Cerroni Lymphoproliferative lesions of the skin. J. Clin. Pathol., August 1, 2006; 59(8): 813 - 826. [Abstract] [Full Text] [PDF] R. Dijkman, C. P. Tensen, M. Buettner, G. Niedobitek, R. Willemze, and M. H. 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