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Blood, 1 January 2005, Vol. 105, No. 1, pp. 13-21. Prepublished online as a Blood First Edition Paper on September 7, 2004; DOI 10.1182/blood-2004-04-1596. This Article Full Text (PDF) All Versions of this Article: 2004-04-1596v1 105/1/13    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by June, C. H Articles by Riley, J. L Search for Related Content PubMed PubMed Citation Articles by June, C. H Articles by Riley, J. L Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 27, 2004 Accepted August 2, 2004 The CD28 Family: a T Cell Rheostat for Therapeutic Control of T Cell Activation Carl H June* and James L Riley Abramson Family Cancer Research Institute and the Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA * Corresponding author; email: cjune{at}mail.med.upenn.edu. The CD28 family of receptors (CD28, CTLA-4, ICOS, PD-1 and BTLA) plays a critical role in controlling the adaptive arm of the immune response. While considerable information is available regarding CD28 and CTLA-4, the function of the more recently discovered members of the CD28 family is less well understood. This review will highlight recent findings regarding the CD28 family with special emphasis on effects the CD28 family has on immunopathology, the discovery of costimulatory antibodies with superagonist function, and the status of clinical trials employing various strategies to augment or block T cell costimulation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. M. Ansell, S. A. Hurvitz, P. A. Koenig, B. R. LaPlant, B. F. Kabat, D. Fernando, T. M. Habermann, D. J. Inwards, M. Verma, R. Yamada, et al. Phase I Study of Ipilimumab, an Anti-CTLA-4 Monoclonal Antibody, in Patients with Relapsed and Refractory B-Cell Non-Hodgkin Lymphoma Clin. Cancer Res., October 15, 2009; 15(20): 6446 - 6453. [Abstract] [Full Text] [PDF] H. M'Hidi, M.-L. Thibult, B. Chetaille, F. Rey, R. Bouadallah, R. Nicollas, D. Olive, and L. 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Parry, J. M. Chemnitz, K. A. Frauwirth, A. R. Lanfranco, I. Braunstein, S. V. Kobayashi, P. S. Linsley, C. B. Thompson, and J. L. Riley CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms Mol. Cell. Biol., November 1, 2005; 25(21): 9543 - 9553. [Abstract] [Full Text] [PDF] H. L. Kaufman and C. R. Divgi Optimizing Prostate Cancer Treatment by Combining Local Radiation Therapy with Systemic Vaccination Clin. Cancer Res., October 1, 2005; 11(19): 6757 - 6762. [Full Text] [PDF] S. Chikuma, A. K. Abbas, and J. A. Bluestone B7-Independent Inhibition of T Cells by CTLA-4 J. Immunol., July 1, 2005; 175(1): 177 - 181. [Abstract] [Full Text] [PDF] L. C. Gonzalez, K. M. Loyet, J. Calemine-Fenaux, V. Chauhan, B. Wranik, W. Ouyang, and D. L. Eaton A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator PNAS, January 25, 2005; 102(4): 1116 - 1121. [Abstract] [Full Text] [PDF]

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