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Blood, 1 December 2004, Vol. 104, No. 12, pp. 3490-3493. Prepublished online as a Blood First Edition Paper on August 3, 2004; DOI 10.1182/blood-2004-04-1642. This Article Full Text (PDF) All Versions of this Article: 2004-04-1642v1 104/12/3490    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sanz, M. A Articles by Martin, G. Search for Related Content PubMed PubMed Citation Articles by Sanz, M. A Articles by Martin, G. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 29, 2004 Accepted July 6, 2004 All-trans retinoic acid and anthracycline monochemotherapy for the treatment of elderly patients with acute promyelocytic leukemia Miguel A Sanz*, Edo Vellenga, Chelo Rayon, Joaquin Diaz-Mediavilla, Concha Rivas, Elena Amutio, Jesus Arias, Guillermo Deben, Andres Novo, Juan Bergua, Javier de la Serna, Javier Bueno, Silvia Negri, Jose M Beltran de Heredia, and Guillermo Martin Department of Hematology, Hospital Universitario La Fe, Valencia, Spain Department of Hematology, University Hospital Groningen, Groningen, The Netherlands Department of Hematology, Hospital Central de Asturias, Oviedo, Spain Department of Hematology, Hospital Clinico San Carlos, Madrid, Spain Department of Hematology, Hospital General de Alicante, Alicante, Spain Department of Hematology, Hospital de Cruces, Baracaldo, Spain Department of Hematology, Complexo Hospitalario Xeral Calde, Lugo, Spain Department of Hematology, Hospital Juan Canalejo, La Coruna, Spain Department of Hematology, Hospital Son Dureta, Palma de Mallorca, Spain Department of Hematology, Hospital San Pedro de Alcantara, Caceres, Spain Department of Hematology, Hospital 12 de Octubre, Madrid, Spain Department of Hematology, Hospital Vall dHebron, Barcelona, Spain Department of Hematology, Hospital Carlos Haya, Malaga, Spain Department of Hematology, Basurtuko Ospitalea, Basurto, Spain * Corresponding author; email: msanz{at}uv.es. Therapeutic results in elderly patients with acute promyelocytic leukemia (APL) have been generally reported as less effective than for younger patients. Patients 60 years or older with APL who were enrolled in two successive multicenter PETHEMA studies received induction therapy with all-trans retinoic acid (ATRA) and idarubicin, consolidation with three anthracycline monochemotherapy courses with or without ATRA, and maintenance with ATRA and low dose chemotherapy. Eighty-seven of 104 patients achieved complete remission (84%). Eighty-six proceeded to consolidation therapy (two withdrew after the first and second courses). Deaths in remission occurred during consolidation and maintenance therapy in three and four patients, respectively. One patients showed molecular persistence after consolidation and five relapsed. The six-year cumulative incidence of relapse, leukemia-free and disease-free survival were 8.5%, 91% and 79%, respectively. A significantly higher incidence of low-risk patients found among the elderly, as compared to younger patients, may partially account for the low relapse rate observed. This study confirms the high antileukemic efficacy, low toxicity and high degree of compliance of protocols using ATRA and anthracycline monochemotherapy for induction and consolidation therapy in elderly patients. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. A. Sanz, D. Grimwade, M. S. Tallman, B. Lowenberg, P. Fenaux, E. H. Estey, T. Naoe, E. Lengfelder, T. Buchner, H. Dohner, et al. Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet Blood, February 26, 2009; 113(9): 1875 - 1891. [Abstract] [Full Text] [PDF] F. Ravandi, E. Estey, D. Jones, S. Faderl, S. O'Brien, J. Fiorentino, S. Pierce, D. Blamble, Z. Estrov, W. Wierda, et al. 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