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Blood, 1 May 2005, Vol. 105, No. 9, pp. 3405-3412. Prepublished online as a Blood First Edition Paper on November 16, 2004; DOI 10.1182/blood-2004-04-1648. This Article Full Text (PDF) All Versions of this Article: 2004-04-1648v1 105/9/3405    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Paoletti, S. Articles by Gerber, B. O Search for Related Content PubMed PubMed Citation Articles by Paoletti, S. Articles by Gerber, B. O Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 29, 2004 Accepted October 25, 2004 A rich chemokine environment strongly enhances leukocyte migration and activities Samantha Paoletti, Vibor Petkovic, Silvia Sebastiani, M G Danelon, Mariagrazia Uguccioni*, and Basil O Gerber Institute for Research in Biomedicine, Bellinzona, Switzerland * Corresponding author; email: mariagrazia.uguccioni{at}irb.unisi.ch. The migration of leukocytes in immune surveillance and inflammation is largely determined by their response to chemokines. While the chemokine specificities and expression patterns of chemokine receptors are well defined, it is still a matter of debate how leukocytes integrate the messages provided by different chemokines that are concomitantly produced in physiological or pathological situations in vivo. We present evidence for a novel regulatory mechanism of leukocyte trafficking. Our data are consistent with a mode of action where CC-chemokine receptor 7 (CCR7) agonists and unrelated, non-agonist chemokines first form a heteromeric complex, in the presence of which the triggering of CCR7 can occur at much lower agonist concentration. The increase is synergistic and can be evoked by many but not all chemokines. Chemokine-induced synergism might provide an amplification system in 'chemokine-rich' tissues, rendering leukocytes more competent to respond to migratory cues. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Chemokines and chemokine receptors: here, there, and everywhere Helene F. Rosenberg Blood 2005 105: 3388. [Full Text] [PDF] This article has been cited by other articles: S. Cepok, H. Schreiber, S. Hoffmann, D. Zhou, O. Neuhaus, G. von Geldern, S. Hochgesand, S. Nessler, V. Rothhammer, M. Lang, et al. Enhancement of Chemokine Expression by Interferon Beta Therapy in Patients With Multiple Sclerosis Arch Neurol, October 1, 2009; 66(10): 1216 - 1223. [Abstract] [Full Text] [PDF] Z. Bai, H. Hayasaka, M. Kobayashi, W. Li, Z. Guo, M. H. Jang, A. Kondo, B.-i. Choi, Y. Iwakura, and M. Miyasaka CXC Chemokine Ligand 12 Promotes CCR7-Dependent Naive T Cell Trafficking to Lymph Nodes and Peyer's Patches J. Immunol., February 1, 2009; 182(3): 1287 - 1295. [Abstract] [Full Text] [PDF] M. C. Picchio, E. Scala, D. Pomponi, E. Caprini, M. Frontani, I. Angelucci, A. Mangoni, C. Lazzeri, M. Perez, D. Remotti, et al. CXCL13 Is Highly Produced by Sezary Cells and Enhances Their Migratory Ability via a Synergistic Mechanism Involving CCL19 and CCL21 Chemokines Cancer Res., September 1, 2008; 68(17): 7137 - 7146. [Abstract] [Full Text] [PDF] I. V. Nesmelova, Y. Sham, J. Gao, and K. H. Mayo CXC and CC Chemokines Form Mixed Heterodimers: ASSOCIATION FREE ENERGIES FROM MOLECULAR DYNAMICS SIMULATIONS AND EXPERIMENTAL CORRELATIONS J. Biol. Chem., August 29, 2008; 283(35): 24155 - 24166. [Abstract] [Full Text] [PDF] M. Gouwy, S. Struyf, S. Noppen, E. Schutyser, J.-Y. Springael, M. Parmentier, P. Proost, and J. Van Damme Synergy between Coproduced CC and CXC Chemokines in Monocyte Chemotaxis through Receptor-Mediated Events Mol. Pharmacol., August 1, 2008; 74(2): 485 - 495. [Abstract] [Full Text] [PDF] G. Bernardini, G. Sciume, D. Bosisio, S. Morrone, S. Sozzani, and A. Santoni CCL3 and CXCL12 regulate trafficking of mouse bone marrow NK cell subsets Blood, April 1, 2008; 111(7): 3626 - 3634. [Abstract] [Full Text] [PDF] S. E. Crown, Y. Yu, M. D. Sweeney, J. A. Leary, and T. M. Handel Heterodimerization of CCR2 Chemokines and Regulation by Glycosaminoglycan Binding J. Biol. Chem., September 1, 2006; 281(35): 25438 - 25446. [Abstract] [Full Text] [PDF] C. A. Lunn, J. S. Fine, A. Rojas-Triana, J. V. Jackson, X. Fan, T. T. Kung, W. Gonsiorek, M. A. Schwarz, B. Lavey, J. A. Kozlowski, et al. A Novel Cannabinoid Peripheral Cannabinoid Receptor-Selective Inverse Agonist Blocks Leukocyte Recruitment in Vivo J. Pharmacol. Exp. Ther., February 1, 2006; 316(2): 780 - 788. [Abstract] [Full Text] [PDF]

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