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Blood, 15 March 2005, Vol. 105, No. 6, pp. 2608-2613. Prepublished online as a Blood First Edition Paper on November 16, 2004; DOI 10.1182/blood-2004-04-1667. This Article Full Text (PDF) All Versions of this Article: 2004-04-1667v1 105/6/2608    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Clave, E. Articles by Toubert, A. Search for Related Content PubMed PubMed Citation Articles by Clave, E. Articles by Toubert, A. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 30, 2004 Accepted November 8, 2004 Prognostic value of pretransplant host thymic function in HLA identical sibling hematopoietic stem cell transplantation Emmanuel Clave*, Vanderson Rocha, Kimmo Talvensaari, Marc Busson, Corinne Douay, Marie-Lorraine Appert, Claire Rabian, Maryvonnick Carmagnat, Federico Garnier, Alain Filion, Gerard Socie, Eliane Gluckman, Dominique Charron, and Antoine Toubert Institut Universitaire d'Hematologie, Laboratoire d'Immunologie et d'Histocompatibilite AP-HP, INSERM U396, Paris, France Hopital st-Louis, AP-HP, Service d'Hematologie-Greffe de Moelle, Paris, France Department of Tissue Typing, Finnish Bone Marrow Donor Registry, Finnish Red Cross Blood Transfusion Service, Helsinki, Finland Hopital st-Louis, AP-HP, Service d'Hematologie-Greffe de Moelle, Paris, France; Institut Universitaire d'Hematologie, INSERM ERM0220, Paris, France * Corresponding author; email: clave{at}histo.chu-stlouis.fr. Thymic function is critical for immune reconstitution after hematopoietic stem cell transplantation (HSCT). We evaluated recipient thymic function before HSCT by quantifying T-cell receptor excision circles (TREC) in pretransplant peripheral blood lymphocytes from 102 patients who received an HLA-identical sibling HSCT for malignant (n=87) or non-malignant diseases (n=15). Median TREC value before transplant was 257/150,000 CD3+ cells (range 0-42746). We assessed 172 TREC/150,000 CD3+ as the most discriminating TREC value for survival in a first cohort of patients (n=62). This cut-off was validated in a second independent prospective group of 40 patients. On the 102 patients, TREC 172 was associated with a better survival (p < 0.00001), a decreased incidence of grade [II-IV] acute GvHD (p=0.017), chronic GVHD (p=0.023), bacterial (p=0.003) and CMV infection (p=0.024). In multivariate analysis, low pretransplant TREC were associated with a higher incidence of CMV infection (HR=2.0, p=0.06) and severe bacterial infections (HR=2.8, p=0.036). Finally, high TREC (HR=6.6, p=0.002) and ABO incompatibility (HR=2.7, p=0.02) were associated with a better survival. Therefore, recipient host thymic function assessment could be helpful in predicting HSCT outcome and identifying patients who require a close immunological monitoring. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. Clave, M. Busson, C. Douay, R. Peffault de Latour, J. Berrou, C. Rabian, M. Carmagnat, V. Rocha, D. Charron, G. Socie, et al. Acute graft-versus-host disease transiently impairs thymic output in young patients after allogeneic hematopoietic stem cell transplantation Blood, June 18, 2009; 113(25): 6477 - 6484. [Abstract] [Full Text] [PDF] L. Cosmi, R. De Palma, V. Santarlasci, L. Maggi, M. Capone, F. Frosali, G. Rodolico, V. Querci, G. Abbate, R. Angeli, et al. Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor J. Exp. Med., August 4, 2008; 205(8): 1903 - 1916. [Abstract] [Full Text] [PDF] E. Gluckman Immune reconstitution after unrelated cord blood transplants in adults Blood, December 15, 2007; 110(13): 4136 - 4136. [Full Text] [PDF] M. Robin, S. Marque-Juillet, C. Scieux, R. P. de Latour, C. Ferry, V. Rocha, J.-M. Molina, A. Bergeron, A. Devergie, E. Gluckman, et al. Disseminated adenovirus infections after allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcome Haematologica, September 1, 2007; 92(9): 1254 - 1257. [Abstract] [Full Text] [PDF] Y. Sakoda, D. Hashimoto, S. Asakura, K. Takeuchi, M. Harada, M. Tanimoto, and T. Teshima Donor-derived thymic-dependent T cells cause chronic graft-versus-host disease Blood, February 15, 2007; 109(4): 1756 - 1764. [Abstract] [Full Text] [PDF]

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