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Blood, 15 January 2005, Vol. 105, No. 2, pp. 862-864. Prepublished online as a Blood First Edition Paper on September 14, 2004; DOI 10.1182/blood-2004-05-1841. This Article Full Text (PDF) All Versions of this Article: 2004-05-1841v1 105/2/862    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sensebe, L. Articles by Senecal, D. Search for Related Content PubMed PubMed Citation Articles by Sensebe, L. Articles by Senecal, D. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted May 14, 2004 Accepted August 27, 2004 The efficiency of transfusing high doses of platelets in hematological patients with thrombocytopenia: results of a prospective, randomized, open, blinded end point (PROBE) study Luc Sensebe*, Bruno Giraudeau, Laurent Bardiaux, Eric Deconinck, Aline Schmidt, Marie-Laure Bidet, Catherine LeNiger, Elisabeth Hardy, Catherine Babault, and Delphine Senecal EFS Centre-Atlantique, Tours, France INSERM CIC202, Tours, France EFS Franche-Comte, Besancon, France Department of Hematology, University Hospital, Besancon, France Department of Hematology, University Hospital, Angers, France EFS Pays de Loire, Angers, France Department of Hematology, University Hospital, Brest, France EFS Bretagne, Brest, France Department of Hematology, University Hospital, Tours, France * Corresponding author; email: luc.sensebe{at}efs.sante.fr. We performed a prospective, randomized, open, blinded end point (PROBE) study to assess the efficiency of transfusing high doses of platelets in patients with thrombocytopenia, either acute leukemia (AL) or those undergoing autologous hematopoietic stem cell transplantation (AT). Patients were randomly assigned to receive transfusions with a target dose of 0.5x1011plts/10 kg (arm A) or 1.0x1011plts/10 kg (arm B). A total of 101 patients were included, of whom 96 were given at least 1 transfusion. The median time between the first transfusion and when the platelet count reached at least 20x109/L increased from 63 hr to 95 hr in the arm B group(p=0.001), and the median number of transfusions was lower in this group (2, p=0.037). The total number of transfused platelets did not differ between groups (14.9x1011, arm A vs 18.5x1011, arm B, p=0.156). In such patients, a prophylactic strategy of high doses of platelets could improve platelet transfusion efficiency. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: The more the better? Andreas Greinacher Blood 2005 105: 442. [Full Text] [PDF] This article has been cited by other articles: C.-Y. Chen, C.-H. Tai, W. Tsay, P.-Y. Chen, and H.-F. Tien Prediction of fatal intracranial hemorrhage in patients with acute myeloid leukemia Ann. Onc., June 1, 2009; 20(6): 1100 - 1104. [Abstract] [Full Text] [PDF] N. M. Heddle, R. J. Cook, A. Tinmouth, C. T. Kouroukis, T. Hervig, E. Klapper, J. M. Brandwein, Z. M. Szczepiorkowski, J. P. AuBuchon, R. L. Barty, et al. A randomized controlled trial comparing standard- and low-dose strategies for transfusion of platelets (SToP) to patients with thrombocytopenia Blood, February 12, 2009; 113(7): 1564 - 1573. [Abstract] [Full Text] [PDF] M. A. Blajchman, S. J. Slichter, N. M. Heddle, and M. F. Murphy New Strategies for the Optimal Use of Platelet Transfusions Hematology, January 1, 2008; 2008(1): 198 - 204. [Abstract] [Full Text] [PDF]

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