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Blood, 15 January 2005, Vol. 105, No. 2, pp. 679-681. Prepublished online as a Blood First Edition Paper on September 9, 2004; DOI 10.1182/blood-2004-05-1906. This Article Full Text (PDF) Supplemental Data All Versions of this Article: 2004-05-1906v1 105/2/679    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Conejo-Garcia, J. R Articles by Coukos, G. Search for Related Content PubMed PubMed Citation Articles by Conejo-Garcia, J. R Articles by Coukos, G. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted May 18, 2004 Accepted August 27, 2004 Vascular Leukocytes Contribute to Tumor Vascularization Jose R Conejo-Garcia, Ronald J Buckanovich, Fabian Benencia, Maria C Courreges, Stephen C Rubin, Richard G Carroll, and George Coukos* Center for Research in Reproduction and Women's Health, University of Pennsylvania, Philadelphia, PA, USA Division of Gynecologic Oncology, University of Pennsylvania, Philadelphia, PA, USA Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA; Center for Research in Reproduction and Women's Health, University of Pennsylvania, Philadelphia, PA, USA; Division of Gynecologic Oncology, University of Pennsylvania, Philadelphia, PA, USA * Corresponding author; email: gcks{at}mail.med.upenn.edu. There is no proof that hematopoetic cells contribute significantly to vasculogenesis in postnatal life. Here we report a novel leukocyte subset within ovarian carcinoma which co-expresses endothelial and dendritic cell markers. FACS analysis identified a high frequency of VE-cadherin+CD45+ leukocytes (39% of host cells) in 10 of 10 solid tumors evaluated. This population represented <1% of non-tumor cells in ascites and peripheral blood. At the protein level, more than 86% of these cells expressed the endothelial markers P1H12, CD34 and CD31, and leukocyte markers CD11c and MHC-II. At the mRNA level, we detected TEM1, TEM7, and Thy-1, specific markers of angiogenic endothelium. Finally, this population has the capacity to generate functional blood vessels in vivo. Because of their mixed phenotype, we named this population "vascular leukocytes" (VLCs). Our data provide an important link between hematopoetic endothelial precursors and vascular development in postnatal life and a possible novel therapeutic target. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: U. K. Scarlett, J. R. Cubillos-Ruiz, Y. C. Nesbeth, D. G. Martinez, X. Engle, A. T. Gewirtz, C. L. Ahonen, and J. R. Conejo-Garcia In situ Stimulation of CD40 and Toll-like Receptor 3 Transforms Ovarian Cancer-Infiltrating Dendritic Cells from Immunosuppressive to Immunostimulatory Cells Cancer Res., September 15, 2009; 69(18): 7329 - 7337. [Abstract] [Full Text] [PDF] G. Cao, M. L. Fehrenbach, J. T. Williams, J. M. Finklestein, J.-X. Zhu, and H. M. DeLisser Angiogenesis in Platelet Endothelial Cell Adhesion Molecule-1-Null Mice Am. J. Pathol., August 1, 2009; 175(2): 903 - 915. [Abstract] [Full Text] [PDF] B. Li, A. Vincent, J. Cates, D. M. Brantley-Sieders, D. B. Polk, and P. P. 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