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Blood, 15 July 2005, Vol. 106, No. 2, pp. 447-453. Prepublished online as a Blood First Edition Paper on January 27, 2005; DOI 10.1182/blood-2004-05-1971. This Article Full Text (PDF) All Versions of this Article: 2004-05-1971v1 106/2/447    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Testi, A. M. Articles by Mandelli, F. Search for Related Content PubMed PubMed Citation Articles by Testi, A. M. Articles by Mandelli, F. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 7, 2004 Accepted December 20, 2004 GIMEMA-AIEOP AIDA protocol for the treatment of newly diagnosed acute promyelocytic leukemia (APL) in children Anna Maria Testi*, Andrea Biondi, Francesco Lo Coco, Maria Luisa Moleti, Fiorina Giona, Marco Vignetti, Giuseppe Menna, Franco Locatelli, Andrea Pession, Elena Barisone, Giulio De Rossi, Daniela Diverio, Concetta Micalizzi, Maurizio Arico, Giuseppe Basso, Robert Foa, and Franco Mandelli Dipartimento di Biotecnologie Cellulari ed Ematologia, Universita 'La Sapienza', Roma, Italy Clinica Pediatrica, Ospedale Nuovo 'San Gerardo', Monza, Italy Dipartimento di Biopatologia e Diagnostica per Immagini, Universita 'Tor Vergata', Roma, Italy Divisione Pediatria Ematologia, Ospedale Pausilipon, Napoli, Italy Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, Pavia, Italy Dipartimento di Pediatria, Universita di Bologna, Bologna, Italy Dipartimento Scienze Pediatriche Adolescenza, Universita di Torino, Torino, Italy Divisione Ematologia Pediatrica, Ospedale Bambin Gesu, Roma, Italy Dipartimento di Ematologia-Oncologia, Istituto Giannina Gaslini, Genova, Italy Oncoematologia Pediatrica, Ospedale dei Bambini, Palermo, Italy Clinica Pediatrica, Universita di Padova, Padova, Italy * Corresponding author; email: testi{at}bce.uniroma1.it. The role of all-trans retinoic acid (ATRA) in pediatric acute promyelocytic leukemia (APL) is the topic of several ongoing studies. The results of the Italian pediatric experience with the multicentric GIMEMA-AIEOP "AIDA" trial are presented. Of the 983 patients with APL enrolled in this protocol between January 1993 and June 2000, 124 (13%) had less than 18 years. Treatment consisted of ATRA and Idarubicin induction followed by 3 polychemotherapy consolidation courses. Molecular response by RT-PCR was assessed after consolidation and patients who were PCR-negative were randomized for different maintenances. One hundred and seven children were eligible and evaluable for induction: 103 (96%) achieved an hematological complete remission. Overt ATRA syndrome was observed in 2 patients and pseudotumor cerebri in 10. Ninety four patients were evaluable for RT-PCR analysis at the end of consolidation: 91 (97%) proved PCR-negative and 3 PCR-positive. The overall survival and event-free-survival (EFS) are 89% (95% c.i: 83-95%) and 76% (c.i: 65-85%), respectively, at more than 10 years. The WBC count at diagnosis > 10 x 109/l had a significant impact on EFS (59% vs 83%, at 10 years). These results highlight the efficacy and feasibility of the AIDA protocol in the pediatric APL population. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: APL treatment Italian style: is this the cure? James Feusner Blood 2005 106: 392-393. [Full Text] [PDF] This article has been cited by other articles: M. A. Sanz, D. Grimwade, M. S. Tallman, B. Lowenberg, P. Fenaux, E. H. Estey, T. Naoe, E. Lengfelder, T. Buchner, H. Dohner, et al. Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet Blood, February 26, 2009; 113(9): 1875 - 1891. [Abstract] [Full Text] [PDF] Z.-Y. Wang and Z. 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