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Blood, 15 November 2004, Vol. 104, No. 10, pp. 3400-3407. Prepublished online as a Blood First Edition Paper on July 27, 2004; DOI 10.1182/blood-2004-05-2046. This Article Full Text (PDF) All Versions of this Article: 2004-05-2046v1 104/10/3400    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dispenzieri, A. Articles by Gertz, M. A Search for Related Content PubMed PubMed Citation Articles by Dispenzieri, A. Articles by Gertz, M. A Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 1, 2004 Accepted July 6, 2004 Peripheral Blood Stem Cell Transplant (PBSCT) In Sixteen Patients With POEMS Syndrome, And A Review Of The Literature Angela Dispenzieri*, Alvaro Moreno-Aspita, Guillermo A Suarez, Martha Q Lacy, Gerardo Colon-Otero, Ayalew Tefferi, Mark R Litzow, Vivek Roy, William J Hogan, Robert A Kyle, and Morie A Gertz Division of Hematology, Mayo Clinic, Rochester, MN, USA Division of Hematology, Mayo Clinic, Jacksonville, FL, USA Department of Neurology, Mayo Clinic, Rochester, MN, USA * Corresponding author; email: dispenzieri.angela{at}mayo.edu. POEMS syndrome is characterized by peripheral neuropathy (PN), a clonal plasma cell disorder (PCD), organomegaly, endocrinopathy, skin changes, edema, sclerotic bone lesions, and thrombocytosis. Based on the improved response rates observed with peripheral blood stem cell transplant (PBSCT) in patients with other PCD, autologous PBSCT may be an attractive treatment option for this syndrome. Sixteen patients with POEMS syndrome have undergone PBSCT at Mayo. Fifteen had a severe rapidly progressive sensorimotor PN (9 wheelchair dependent). Fourteen were male. Median age was 51 years (range 19-62). The median number of prior therapies was 3 (range 0-7). From first symptoms and from diagnosis of POEMS the times to transplant were 42 and 5 months (ranges 8-185 and 2-149), respectively. Fifteen patients had significantly abnormal pre-transplant pulmonary function tests. There was one transplant-related death. During the peri-transplant period, five patients required intubation for respiratory compromise including one during his stem cell mobilization period. Another patient required non-invasive biphasic positive airway pressure throughout his course. Of the 14 evaluable patients, all have had neurologic improvement or stabilization. Other features have improved substantially. PBSCT for POEMS syndrome is effective therapy but may also be associated with significant morbidity. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: POEMS syndrome: definitions and long-term outcome Angela Dispenzieri, Robert A. Kyle, Martha Q. Lacy, S. Vincent Rajkumar, Terry M. Therneau, Dirk R. Larson, Philip R. Greipp, Thomas E. Witzig, Rita Basu, Guillermo A. Suarez, Rafael Fonseca, John A. Lust, and Morie A. Gertz Blood 2003 101: 2496-2506. [Abstract] [Full Text] [PDF] This article has been cited by other articles: S. Kuwabara, S. Misawa, K. Kanai, Y. Suzuki, Y. Kikkawa, S. Sawai, T. Hattori, M. Nishimura, and C. Nakaseko Neurologic improvement after peripheral blood stem cell transplantation in POEMS syndrome Neurology, November 18, 2008; 71(21): 1691 - 1695. [Abstract] [Full Text] [PDF] C. Chalk Making the lame walk?: Transplantation for POEMS Neurology, November 18, 2008; 71(21): 1658 - 1659. [Full Text] [PDF] S Kuwabara, S Misawa, K Kanai, S Sawai, T Hattori, M Nishimura, and C Nakaseko Thalidomide reduces serum VEGF levels and improves peripheral neuropathy in POEMS syndrome J. Neurol. Neurosurg. Psychiatry, November 1, 2008; 79(11): 1255 - 1257. [Abstract] [Full Text] [PDF] D. Abe, C. Nakaseko, M. Takeuchi, H. Tanaka, C. Ohwada, E. Sakaida, Y. Takeda, K. Oda, S. Ozawa, N. Shimizu, et al. Restrictive usage of monoclonal immunoglobulin {lambda} light chain germline in POEMS syndrome Blood, August 1, 2008; 112(3): 836 - 839. [Abstract] [Full Text] [PDF] J. S. Allam, C. C. Kennedy, T. R. Aksamit, and A. Dispenzieri Pulmonary Manifestations in Patients With POEMS Syndrome: A Retrospective Review of 137 Patients Chest, April 1, 2008; 133(4): 969 - 974. [Abstract] [Full Text] [PDF] P.-Y. Dietrich and M. A. Duchosal Bevacizumab therapy before autologous stem-cell transplantation for POEMS syndrome Ann. Onc., March 1, 2008; 19(3): 595 - 595. [Full Text] [PDF] A. Dispenzieri, C. J. Klein, and M. L. Mauermann Lenalidomide therapy in a patient with POEMS syndrome Blood, August 1, 2007; 110(3): 1075 - 1076. [Full Text] [PDF] G. Y. Gandhi, R. Basu, A. Dispenzieri, A. Basu, V. M. Montori, and M. D. Brennan Endocrinopathy in POEMS Syndrome: The Mayo Clinic Experience Mayo Clin. Proc., July 1, 2007; 82(7): 836 - 842. [Abstract] [Full Text] [PDF] S. V. Rajkumar, A. Dispenzieri, and R. A. Kyle Monoclonal Gammopathy of Undetermined Significance, Waldenstrom Macroglobulinemia, AL Amyloidosis, and Related Plasma Cell Disorders: Diagnosis and Treatment Mayo Clin. Proc., May 1, 2006; 81(5): 693 - 703. [Abstract] [Full Text] [PDF] R. Caswell, T. Warner, A. Mehta, and L. Ginsberg POEMS syndrome Practical Neurology, April 1, 2006; 6(2): 111 - 116. [Full Text] [PDF] P. J. Dyck, J. Engelstad, and A. Dispenzieri Vascular endothelial growth factor and POEMS Neurology, January 10, 2006; 66(1): 10 - 12. [Full Text] [PDF] S. Kuwabara, S. Misawa, K. Kanai, Y. Kikkawa, M. Nishimura, C. Nakaseko, R. K. Cho, and T. Hattori Autologous peripheral blood stem cell transplantation for POEMS syndrome Neurology, January 10, 2006; 66(1): 105 - 107. [Abstract] [Full Text] [PDF] D. Pleasure Keeping "Trk" of Paraneoplastic Syndromes Arch Neurol, October 1, 2005; 62(10): 1508 - 1509. [Full Text] [PDF] M. Q. Lacy, W. J. Hogan, M. A. Gertz, A. Dispenzieri, S. V. Rajkumar, S. Hayman, S. Kumar, M. R. Litzow, and A. L. Schroeter Successful Treatment of Scleromyxedema With Autologous Peripheral Blood Stem Cell Transplantation Arch Dermatol, October 1, 2005; 141(10): 1277 - 1282. [Abstract] [Full Text] [PDF] A. Dispenzieri POEMS Syndrome Hematology, January 1, 2005; 2005(1): 360 - 367. [Abstract] [Full Text] [PDF] S. Kuwabara, S. Misawa, K. Kanai, Y. Kikkawa, M. Nishimura, C. Nakaseko, R. K. Cho, and T. Hattori Autologous peripheral blood stem cell transplantation for POEMS syndrome Neurology, January 10, 2006; 66(1): 105 - 107. [Abstract] [Full Text] [PDF]

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