SEARCH:   Advanced

Blood, 15 April 2005, Vol. 105, No. 8, pp. 3286-3294. Prepublished online as a Blood First Edition Paper on December 23, 2004; DOI 10.1182/blood-2004-06-2101. This Article Full Text (PDF) All Versions of this Article: 2004-06-2101v1 105/8/3286    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Zhang, H. Articles by Batuman, O. A Search for Related Content PubMed PubMed Citation Articles by Zhang, H. Articles by Batuman, O. A Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 4, 2004 Accepted December 15, 2004 Circulating endothelial progenitor cells in multiple myeloma: implications and significance Hong Zhang, Varsha Vakil, Marc Braunstein, Eric L Smith, Justin Maroney, Laurie Chen, Kezhi Dai, James R Berenson, M M Hussain, Uwe Klueppelberg, Allen J Norin, Hasan O Akman, Tayfun Ozcelik, and Olcay A Batuman* Division of Hematology/Oncology, Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, NY, USA Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY, USA Institute for Myeloma & Bone Cancer Research, UCLA School of Medicine, Los Angeles, CA, USA Transplant Immunology & Immunogenetics Laboratory, State University of New York Downstate Medical Center, Brooklyn, NY, USA Department of Molecular Biology and Genetics, Ayhan Sahenk Foundation and Bilkent University, Bilkent, Ankara, Turkey * Corresponding author; email: obatuman{at}downstate.edu. Angiogenesis governs the progression of multiple myeloma (MM). Circulating endothelial cells (CECs) contribute to angiogenesis and comprise mature ECs and endothelial progenitor cells (EPCs). The present study sought to characterize CECs and their relation to disease activity and therapeutic response in thirty-one consecutive MM patients. CECs, identified as CD34+/CD146+/CD105+/CD11b- cells, were 6-fold higher in patients compared to controls, and correlated positively with serum M protein and 2-microglobulin. Circulating EPCs displayed late colony formation/outgrowth and capillary-like network formation on Matrigel; these processes were inhibited after effective thalidomide treatment. Co-expression of vascular endothelial growth factor receptor-2 (KDR) and CD133 characterized EPCs in MM, and KDR mRNA elevations correlated with M protein levels. In vitro exposure of ECs to thalidomide or its derivative CC-5013 inhibited gene expression of the receptors for transforming growth factor- and thrombin. Thus, elevated levels of CECs and EPCs covary with disease activity and response to thalidomide, underscoring the angiogenic aspect of MM and suggesting that angioblast-like EPCs are a pathogenic biomarker and a rational treatment target in MM. The results also highlight the anti-angiogenic properties of thalidomide and CC-5013, and further elucidate possible mechanisms of their effectiveness against MM. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Another dangerous traveler in myeloma blood? Joachim Kienast and Wolfgang E. Berdel Blood 2005 105: 3009-3010. [Full Text] [PDF] This article has been cited by other articles: S.-J. Kim, J.-S. Kim, J. Papadopoulos, S. Wook Kim, M. Maya, F. Zhang, J. He, D. Fan, R. Langley, and I. J. Fidler Circulating Monocytes Expressing CD31: Implications for Acute and Chronic Angiogenesis Am. J. Pathol., May 1, 2009; 174(5): 1972 - 1980. [Abstract] [Full Text] [PDF] K. Bogos, F. Renyi-Vamos, J. Dobos, I. Kenessey, J. Tovari, J. Timar, J. Strausz, G. Ostoros, W. Klepetko, H. J. Ankersmit, et al. High VEGFR-3-positive Circulating Lymphatic/Vascular Endothelial Progenitor Cell Level Is Associated with Poor Prognosis in Human Small Cell Lung Cancer Clin. Cancer Res., March 1, 2009; 15(5): 1741 - 1746. [Abstract] [Full Text] [PDF] H. Chen, R. A. Campbell, Y. Chang, M. Li, C. S. Wang, J. Li, E. Sanchez, M. Share, J. Steinberg, A. Berenson, et al. Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis Blood, February 26, 2009; 113(9): 1992 - 2002. [Abstract] [Full Text] [PDF] P. Mancuso, P. Antoniotti, J. Quarna, A. Calleri, C. Rabascio, C. Tacchetti, P. Braidotti, H.-K. Wu, A. J. Zurita, L. Saronni, et al. Validation of a Standardized Method for Enumerating Circulating Endothelial Cells and Progenitors: Flow Cytometry and Molecular and Ultrastructural Analyses Clin. Cancer Res., January 1, 2009; 15(1): 267 - 273. [Abstract] [Full Text] [PDF] R. G. Bagley, C. Rouleau, T. St. Martin, P. Boutin, W. Weber, M. Ruzek, N. Honma, M. Nacht, S. Shankara, S. Kataoka, et al. Human endothelial precursor cells express tumor endothelial marker 1/endosialin/CD248 Mol. Cancer Ther., August 1, 2008; 7(8): 2536 - 2546. [Abstract] [Full Text] [PDF] A. Zampetaki, J. P. Kirton, and Q. Xu Vascular repair by endothelial progenitor cells Cardiovasc Res, June 1, 2008; 78(3): 413 - 421. [Abstract] [Full Text] [PDF] R. Ria, C. Piccoli, T. Cirulli, F. Falzetti, G. Mangialardi, D. Guidolin, A. Tabilio, N. Di Renzo, A. Guarini, D. Ribatti, et al. Endothelial Differentiation of Hematopoietic Stem and Progenitor Cells from Patients with Multiple Myeloma Clin. Cancer Res., March 15, 2008; 14(6): 1678 - 1685. [Abstract] [Full Text] [PDF] B. Guezguez, P. Vigneron, N. Lamerant, C. Kieda, T. Jaffredo, and D. Dunon Dual Role of Melanoma Cell Adhesion Molecule (MCAM)/CD146 in Lymphocyte Endothelium Interaction: MCAM/CD146 Promotes Rolling via Microvilli Induction in Lymphocyte and Is an Endothelial Adhesion Receptor J. Immunol., November 15, 2007; 179(10): 6673 - 6685. [Abstract] [Full Text] [PDF] X. Pan and M. M. Hussain Diurnal Regulation of Microsomal Triglyceride Transfer Protein and Plasma Lipid Levels J. Biol. Chem., August 24, 2007; 282(34): 24707 - 24719. [Abstract] [Full Text] [PDF] M. Ferrario, M. Massa, V. Rosti, R. Campanelli, M. Ferlini, B. Marinoni, G. M. De Ferrari, V. Meli, M. De Amici, A. Repetto, et al. Early haemoglobin-independent increase of plasma erythropoietin levels in patients with acute myocardial infarction Eur. Heart J., August 1, 2007; 28(15): 1805 - 1813. [Abstract] [Full Text] [PDF] L. Mileshkin, D. Honemann, P. Gambell, M. Trivett, Y. Hayakawa, M. Smyth, V. Beshay, D. Ritchie, P. Simmons, A. D. Milner, et al. Patients with multiple myeloma treated with thalidomide: evaluation of clinical parameters, cytokines, angiogenic markers, mast cells and marrow CD57+ cytotoxic T cells as predictors of outcome Haematologica, August 1, 2007; 92(8): 1075 - 1082. [Abstract] [Full Text] [PDF] D. Yu, X. Sun, Y. Qiu, J. Zhou, Y. Wu, L. Zhuang, J. Chen, and Y. Ding Identification and Clinical Significance of Mobilized Endothelial Progenitor Cells in Tumor Vasculogenesis of Hepatocellular Carcinoma Clin. Cancer Res., July 1, 2007; 13(13): 3814 - 3824. [Abstract] [Full Text] [PDF] X. Pan, F. N. Hussain, J. Iqbal, M. H. Feuerman, and M. M. Hussain Inhibiting Proteasomal Degradation of Microsomal Triglyceride Transfer Protein Prevents CCl4-induced Steatosis J. Biol. Chem., June 8, 2007; 282(23): 17078 - 17089. [Abstract] [Full Text] [PDF] K. Asosingh, S. Swaidani, M. Aronica, and S. C. Erzurum Th1- and Th2-Dependent Endothelial Progenitor Cell Recruitment and Angiogenic Switch in Asthma J. Immunol., May 15, 2007; 178(10): 6482 - 6494. [Abstract] [Full Text] [PDF] J. C. McAuliffe and J. C. Trent Biomarkers in Gastrointestinal Stromal Tumor: Should We Equate Blood-Based Pharmacodynamics with Tumor Biology and Clinical Outcomes? Clin. Cancer Res., May 1, 2007; 13(9): 2535 - 2536. [Full Text] [PDF] Y. Oki and A. Younes Endothelial progenitor cells in non-Hodgkin's lymphoma Haematologica, April 1, 2007; 92(4): 433 - 434. [Full Text] [PDF] C. Igreja, M. Courinha, A. S. Cachaco, T. Pereira, J. Cabecadas, M. G. da Silva, and S. Dias Characterization and clinical relevance of circulating and biopsy-derived endothelial progenitor cells in lymphoma patients Haematologica, April 1, 2007; 92(4): 469 - 477. [Abstract] [Full Text] [PDF] I. Ben-Dor, S. Fuchs, and R. Kornowski Potential Hazards and Technical Considerations Associated With Myocardial Cell Transplantation Protocols for Ischemic Myocardial Syndrome J. Am. Coll. Cardiol., October 17, 2006; 48(8): 1519 - 1526. [Abstract] [Full Text] [PDF] N. Mehra, M. Penning, J. Maas, L. V. Beerepoot, N. van Daal, C. H. van Gils, R. H. Giles, and E. E. Voest Progenitor Marker CD133 mRNA Is Elevated in Peripheral Blood of Cancer Patients with Bone Metastases. Clin. Cancer Res., August 15, 2006; 12(16): 4859 - 4866. [Abstract] [Full Text] [PDF] D. G. Duda, K. S. Cohen, E. di Tomaso, P. Au, R. J. Klein, D. T. Scadden, C. G. Willett, and R. K. Jain Differential CD146 Expression on Circulating Versus Tissue Endothelial Cells in Rectal Cancer Patients: Implications for Circulating Endothelial and Progenitor Cells As Biomarkers for Antiangiogenic Therapy J. Clin. Oncol., March 20, 2006; 24(9): 1449 - 1453. [Abstract] [Full Text] [PDF] G. M. Rigolin, C. Fraulini, M. Ciccone, E. Mauro, A. M. Bugli, C. De Angeli, M. Negrini, A. Cuneo, and G. Castoldi Neoplastic circulating endothelial cells in multiple myeloma with 13q14 deletion Blood, March 15, 2006; 107(6): 2531 - 2535. [Abstract] [Full Text] [PDF] A. Rosenzweig Circulating Endothelial Progenitors -- Cells as Biomarkers N. Engl. J. Med., September 8, 2005; 353(10): 1055 - 1057. [Full Text] [PDF]

	Copyright © 2004 by American Society of Hematology         Online ISSN: 1528-0020