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 Blood, 1 January 2005, Vol. 105, No. 1, pp. 394-396.
Prepublished online as a Blood First Edition Paper on August 31, 2004; DOI 10.1182/blood-2004-06-2106.

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Submitted June 3, 2004
Accepted August 19, 2004

Disruption of plasmodium berghei merozoite surface protein 7 gene modulates parasite growth in vivo

Rita Tewari*, Solabomi A Ogun, Ruwani S Gunaratne, Andrea Crisanti, and Anthony A Holder

Department of Biological Sciences, Imperial College, London, United Kingdom
Division of Parasitology, National Institute for Medical Research, London, United Kingdom

* Corresponding author; email: r.tewari{at}imperial.ac.uk.

Merozoite invasion of red cells is crucial to the development of the parasite that causes malaria. Merozoite surface proteins (MSPs) mediate the first interaction between parasite and erythrocyte, and in Plasmodium falciparum include a complex of products from at least 3 genes (msp1, msp6 and msp7). msp7 is part of a gene family containing 3 and 6 adjacent members in Plasmodium yoelii and P. falciparum, respectively. We have identified and disrupted msp7 in the Plasmodium berghei gene family. The protein is expressed in schizonts and colocalizes with MSP1. The synthesis and processing of MSP1 was unaffected in the parasite with the disrupted gene (MSP7ko). Disruption of msp7 was not lethal but affected blood-stage parasite growth. MSP7ko parasites initially grew more slowly than wild type parasites. However, when reticulocytes were prevalent the rate of increase in parasitemia was similar, suggesting that MSP7ko parasites prefer to invade and grow within reticulocytes.


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