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Blood, 1 December 2004, Vol. 104, No. 12, pp. 3535-3542. Prepublished online as a Blood First Edition Paper on August 10, 2004; DOI 10.1182/blood-2004-06-2275. This Article Full Text (PDF) All Versions of this Article: 2004-06-2275v1 104/12/3535    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Maris, M. B Articles by Maloney, D. G Search for Related Content PubMed PubMed Citation Articles by Maris, M. B Articles by Maloney, D. G Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 16, 2004 Accepted July 22, 2004 Allogeneic Hematopoietic Cell Transplantation after Fludarabine and 2 Gy Total Body Irradiation for Relapsed and Refractory Mantle Cell Lymphoma Michael B Maris*, Brenda M Sandmaier, Barry E Storer, Thomas Chauncey, Monic Jain Stuart, Richard T Maziarz, Edward Agura, Amelia A Langston, Michael Pulsipher, Rainer Storb, and David G Maloney Fred Hutchinson Cancer Research Center, Seattle, WA, USA; University of Washington, Seattle, WA, USA Fred Hutchinson Cancer Research Center, Seattle, WA, USA; University of Washington, Seattle, WA, USA; Seattle Veterans Affairs Medical Center, Seattle, WA, USA Stanford University, Palo Alto, CA, USA Oregon Health and Science University, Portland, OR, USA Baylor University, Dallas, TX, USA Emory University, Atlanta, GA, USA University of Utah, Salt Lake City, UT, USA * Corresponding author; email: mmaris{at}fhcrc.org;blarson@fhcrc.org. We carried out HLA-matched related (n=16) and unrelated (n=17) hematopoietic cell transplantation (HCT) in 33 patients with relapsed and refractory mantle cell lymphoma after nonmyeloablative conditioning with fludarabine and 2 Gy total body irradiation. Postgrafting immunosuppression consisted of cyclosporine and mycophenolate mofetil. Fourteen patients had failed high-dose autologous HCT. Thirty-one of the 33 patients had stable engraftment, while 2 patients experienced non-fatal graft rejections. The incidences of acute grades II, III and IV, and chronic GVHD were 27%, 17%, 13%, and 64%, respectively. The overall response rate in the 20 patients with measurable disease at the time of HCT was 85% [n=17; 75% complete remissions (CR) and 10% partial remissions (PR)], while 3 patients had progressive disease. Only 1 of the 17 patients who responded and none of the 13 transplanted in CR had disease relapse with a median follow-up of 24.6 months. Relapse and non-relapse mortalities were 9% and 24%, respectively, at 2 years. The Kaplan-Meier probabilities of overall and disease-free survivals at 2 years were 65% and 60%, respectively. Allogeneic HCT after nonmyeloablative conditioning is a promising salvage strategy for patients with relapsed and refractory mantle cell lymphoma. The high response and low relapse rates with this approach suggest that mantle cell lymphoma is susceptible to graft-versus-tumor responses. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Ghielmini and E. Zucca How I treat mantle cell lymphoma Blood, August 20, 2009; 114(8): 1469 - 1476. [Abstract] [Full Text] [PDF] H. E. Kohrt, B. B. Turnbull, K. Heydari, J. A. Shizuru, G. G. Laport, D. B. Miklos, L. J. Johnston, S. Arai, W.-K. Weng, R. T. Hoppe, et al. 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Sustained Graft-Versus-Lymphoma Effect among Patients (pts) with Mantle Cell Lymphoma (MCL) Given Nonmyeloablative Allogeneic Hematopoietic Cell Transplantation (HCT). Blood (ASH Annual Meeting Abstracts), November 16, 2008; 112(11): 2147 - 2147. [Abstract] [Full Text] B. G. Till, M. C. Jensen, J. Wang, E. Y. Chen, B. L. Wood, H. A. Greisman, X. Qian, S. E. James, A. Raubitschek, S. J. Forman, et al. Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells Blood, September 15, 2008; 112(6): 2261 - 2271. [Abstract] [Full Text] [PDF] F. R. Appelbaum Hematopoietic Cell Transplantation for Non-Hodgkin's Lymphoma: Yesterday, Today, and Tomorrow J. Clin. Oncol., June 20, 2008; 26(18): 2927 - 2929. [Full Text] [PDF] B. S. Kahl New Therapeutic Strategies for Mantle Cell Lymphoma ASCO Educational Book, January 1, 2008; 2008(1): 392 - 397. [Abstract] [Full Text] [PDF] M. L. Sorror, B. E. Storer, D. G. 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