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Blood, 1 January 2005, Vol. 105, No. 1, pp. 301-307. Prepublished online as a Blood First Edition Paper on September 2, 2004; DOI 10.1182/blood-2004-06-2298. This Article Full Text (PDF) Supplemental Data All Versions of this Article: 2004-06-2298v1 105/1/301    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Glas, A. M Articles by de Jong, D. Search for Related Content PubMed PubMed Citation Articles by Glas, A. M Articles by de Jong, D. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 18, 2004 Accepted August 10, 2004 Gene expression profiling in Follicular Lymphoma to assess clinical aggressiveness and to guide the choice of treatment Annuska M Glas, Marie J Kersten, Leonie J Delahaye, Anke T Witteveen, Robby E Kibbelaar, Arno Velds, Lodewyk F Wessels, Peter Joosten, Ron M Kerkhoven, Rene Bernards, Johan H van Krieken, Philip M Kluin, Laura J van 't Veer, and Daphne de Jong* Division of Diagnostic Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; Academic Medical Center, Leeuwarden, The Netherlands Central Laboratory for Public Health Friesland, Leeuwarden, The Netherlands Division of Central Microarray Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands Division of Diagnostic Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; Delft University of Technology, Delft, The Netherlands Friesland Medical Center Leeuwarden, Leeuwarden, The Netherlands University Medical Center Nijmegen, Nijmegen, The Netherlands Groningen University Medical Center, Groningen, The Netherlands * Corresponding author; email: d.d.jong{at}nki.nl. Follicular lymphoma (FL) is a disease characterized by a long clinical course marked by frequent relapses that vary in clinical aggressiveness over time. Therefore, the main dilemma at each relapse is the choice for the most effective treatment for optimal disease control and failure-free survival while at the same time avoiding over-treatment and harmful side effects. The selection for more aggressive treatment is currently based on histological grading and clinical criteria; however, in up to 30% of all cases these methods prove to be insufficient. Using supervised classification on a training set of paired samples from patients who experienced either an indolent or aggressive disease course, a gene-expression profile of 81 genes was established that could, with an accuracy of 100%, distinguish low-grade from high-grade disease. This profile accurately classified 93% of the FL samples in an independent validation set. Most importantly, in a third series of FL, cases where histological grading was ambiguous, precluding meaningful morphological guidance, the 81-gene profile shows a classification accuracy of 94%. The FL-stratification profile is a more reliable marker of clinical behavior than the currently used histological grading and clinical criteria, and may provide an important alternative to guide the choice of therapy in FL patients both at presentation and at relapse. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. Carlotti and J. G. Gribben Stem cell mimicry: key to transformation? Blood, October 8, 2009; 114(15): 3133 - 3134. [Abstract] [Full Text] [PDF] A. J. Gentles, A. A. Alizadeh, S.-I. Lee, J. H. Myklebust, C. M. Shachaf, B. Shahbaba, R. Levy, D. Koller, and S. K. 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