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Blood, 1 February 2005, Vol. 105, No. 3, pp. 1094-1101. Prepublished online as a Blood First Edition Paper on September 30, 2004; DOI 10.1182/blood-2004-06-2315. This Article Full Text (PDF) All Versions of this Article: 2004-06-2315v1 105/3/1094    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Berger, M. Articles by Ganss, R. Search for Related Content PubMed PubMed Citation Articles by Berger, M. Articles by Ganss, R. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 18, 2004 Accepted September 24, 2004 Regulator of G protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization Mario Berger, Gabriele Bergers, Bernd Arnold, Gunter J Hammerling, and Ruth Ganss* Department of Molecular Immunology, German Cancer Research Center, Heidelberg, Germany Department of Neurological Surgery BTRC, University of California Comprehensive Cancer Center, San Francisco, CA, USA * Corresponding author; email: r.ganss{at}dkfz.de. We identified regulator of G-protein signaling-5 (RGS-5) as an angiogenic pericyte marker at sites of physiological and pathological angiogenesis. In a mouse model of pancreatic islet cell carcinogenesis, RGS-5 is specifically induced in the vasculature of premalignant lesions during the 'angiogenic switch', and further elevated in tumor vessels. Similarly, RGS-5 is overexpressed in highly angiogenic astrocytomas but not in hypoxia-inducible factor-1 (HIF-1)-deficient tumors, which grow along pre-existing brain capillaries without inducing neovessels. Elevated levels of RGS-5 in pericytes are also observed during wound healing and ovulation indicating a strong correlation between RGS-5 expression and active vessel remodeling beyond tumor angiogenesis. Moreover, anti-tumor therapy, which reverses tumor vasculature to an almost normal morphology, results in down-regulation of RGS-5 transcription. Taken together, these data demonstrate for the first time a factor that is specific for 'activated' pericytes. This further supports the notion that pericytes, like endothelial cells, undergo molecular changes during neovascularization that makes them a novel target for anti-angiogenic therapy. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Cho, C. 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