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Blood, 1 February 2005, Vol. 105, No. 3, pp. 1170-1178. Prepublished online as a Blood First Edition Paper on September 30, 2004; DOI 10.1182/blood-2004-06-2336. This Article Full Text (PDF) All Versions of this Article: 2004-06-2336v1 105/3/1170    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kim, A. Y Articles by Walker, B. D Search for Related Content PubMed PubMed Citation Articles by Kim, A. Y Articles by Walker, B. D Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 18, 2004 Accepted September 21, 2004 The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T cell count in HIV-1 coinfected individuals Arthur Y Kim, Georg M Lauer, Kei Ouchi, Marylyn M Addo, Michaela Lucas, Julian Schulze zur Wiesch, Joerg Timm, Melinda Boczanowski, Jared E Duncan, Alysse G Wurcel, Deborah Casson, Raymond T Chung, Rika Draenert, Paul Klenerman, and Bruce D Walker* Partners AIDS Resarch Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, Oxford University, Oxford, United Kingdom Partners AIDS Resarch Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA Partners AIDS Resarch Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Lemuel Shattuck Hospital, Jamaica Plain, Massachusetts, USA Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA * Corresponding author; email: bwalker{at}partners.org. CD8+ T cell responses are an essential antiviral host defense in persistent viral infections, and their sustained effectiveness is thought to be critically dependent on CD4+ T helper cells. To determine the relationship between HIV-1-induced CD4+ T cell depletion and HCV-specific CD8+ T cell responses during viral persistence, we studied 103 HCV positive persons, 74 coinfected with HIV-1. CD8+ T cell responses to the entire HCV polyprotein were determined using an interferon-gamma ELISpot assay. Although HIV-1 infection by itself was not associated with a diminished HCV-specific response, HIV-1-associated CD4+ depletion was associated with significantly lower HCV-specific CD8+ T cells (R=0.48, p <0.0001). In contrast, declining CD4+ counts over the same range were not associated with diminished EBV- (R=0.19, p=0.31) or HIV-1-specific (R=-0.13, p=0.60) CD8+ T cell responses in persons infected with all viruses. These data indicate that frequencies of circulating HCV-specific CD8+ T cell responses are sensitive to absolute CD4+ T cell counts and provide a possible explanation for the accelerated HCV disease course in persons coinfected with HIV-1 and HCV. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: V. D. Gonzalez, K. Falconer, K. G. Blom, O. Reichard, B. Morn, A. L. Laursen, N. Weis, A. Alaeus, and J. K. Sandberg High Levels of Chronic Immune Activation in the T-Cell Compartments of Patients Coinfected with Hepatitis C Virus and Human Immunodeficiency Virus Type 1 and on Highly Active Antiretroviral Therapy Are Reverted by Alpha Interferon and Ribavirin Treatment J. Virol., November 1, 2009; 83(21): 11407 - 11411. [Abstract] [Full Text] [PDF] J. J. Chang, S. Sirivichayakul, A. Avihingsanon, A. J. V. Thompson, P. Revill, D. Iser, J. Slavin, S. Buranapraditkun, P. Marks, G. Matthews, et al. 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