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Blood, 1 February 2005, Vol. 105, No. 3, pp. 1121-1126. Prepublished online as a Blood First Edition Paper on October 12, 2004; DOI 10.1182/blood-2004-06-2344. This Article Full Text (PDF) Supplemental Figure All Versions of this Article: 2004-06-2344v1 105/3/1121    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Leu, C.-M. Articles by Cooper, M. D Search for Related Content PubMed PubMed Citation Articles by Leu, C.-M. Articles by Cooper, M. D Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 21, 2004 Accepted September 10, 2004 FcRH1: an activation co-receptor on human B cells Chuen-Miin Leu, Randall S Davis, Lanier A Gartland, W D Fine, and Max D Cooper* Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL, USA Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL, USA; Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL, USA Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL, USA; Howard Hughes Medical Institute, Birmingham, AL, USA Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL, USA; Departments of Medicine, Pathology, Pediatrics, and Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA; Howard Hughes Medical Institute, Birmingham, AL, USA * Corresponding author; email: david.fine{at}ccc.uab.edu. B cell activation and differentiation is regulated through the coordinated function of a dynamic array of cell surface receptors. At different stages in their differentiation, human B cells may express one or more members of a large family of immunoglobulin Fc receptor homologs (FcRH) with regulatory potential. Among these newly identified transmembrane molecules, FcRH1 is unique in having two ITAM-like motifs in its intracellular domain. Here we employed the Fab fragments of new monoclonal anti-FcRH1 antibodies and mRNA analysis to evaluate FcRH1 expression and function during B cell differentiation. FcRH1 expression begins in pre-B cells, reaches peak levels on naive B cells, and is down-regulated after B cells are activated to begin to form germinal centers. This FcRH1 down-regulation coincides with dramatic enlargement of the pre-germinal center cells, cell cycle entry, and other overt signs of activation that include CD80 and CD86 up-regulation and IgD and CD69 down-regulation. In vitro analysis indicates that ligation of FcRH1 leads to its tyrosine phosphorylation and to modest B cell activation and proliferation. Concommitant FcRH1 ligation enhances BCR-induced Ca2+ mobilization and proliferation. FcRH1 thus has the potential to serve as an activating co-receptor on B cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: F. J. Li, S. Ding, J. Pan, M. A. Shakhmatov, E. Kashentseva, J. Wu, Y. Li, S.-j. Soong, N. Chiorazzi, and R. S. Davis FCRL2 expression predicts IGHV mutation status and clinical progression in chronic lymphocytic leukemia Blood, July 1, 2008; 112(1): 179 - 187. [Abstract] [Full Text] [PDF] X. Du, S. Nagata, T. Ise, M. Stetler-Stevenson, and I. Pastan FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins Blood, January 1, 2008; 111(1): 338 - 343. [Abstract] [Full Text] [PDF] W.-J. Won, J. B. Foote, M. R. Odom, J. Pan, J. F. Kearney, and R. S. Davis Fc Receptor Homolog 3 Is a Novel Immunoregulatory Marker of Marginal Zone and B1 B Cells J. Immunol., November 15, 2006; 177(10): 6815 - 6823. [Abstract] [Full Text] [PDF] A. G. Polson, B. Zheng, K. Elkins, W. Chang, C. Du, P. Dowd, L. Yen, C. Tan, J.-A. Hongo, H. Koeppen, et al. Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia Int. Immunol., September 1, 2006; 18(9): 1363 - 1373. [Abstract] [Full Text] [PDF] J. Mohan, J. Dement-Brown, S. Maier, T. Ise, B. Kempkes, and M. Tolnay Epstein-Barr virus nuclear antigen 2 induces FcRH5 expression through CBF1 Blood, June 1, 2006; 107(11): 4433 - 4439. [Abstract] [Full Text] [PDF] G. R.A. Ehrhardt, J. T. Hsu, L. Gartland, C.-M. Leu, S. Zhang, R. S. Davis, and M. D. Cooper Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells J. Exp. Med., September 19, 2005; 202(6): 783 - 791. [Abstract] [Full Text] [PDF]

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