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Blood, 1 July 2005, Vol. 106, No. 1, pp. 67-74. Prepublished online as a Blood First Edition Paper on March 22, 2005; DOI 10.1182/blood-2004-06-2350. This Article Full Text (PDF) All Versions of this Article: 2004-06-2350v1 106/1/67    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Horiguchi, H. Articles by Kayama, F. Search for Related Content PubMed PubMed Citation Articles by Horiguchi, H. Articles by Kayama, F. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 21, 2004 Accepted March 4, 2005 The effects of iron deficiency on estradiol-induced suppression of erythropoietin induction in rats: implications of pregnancy-related anemia Hyogo Horiguchi*, Etsuko Oguma, and Fujio Kayama Division of Environmental Medicine, Center for Community Medicine, Jichi Medical School, Tochigi, Japan; Core Research for Evolutional Science and Technology, Japan Science Technology Corporation (CREST-JST), Saitama, Japan * Corresponding author; email: hhyogo{at}jichi.ac.jp. Pregnant women often develop anemia concomitant with the increase in serum erythropoietin levels, which are actually lower than those of non-pregnant anemic women due to the possible suppressive effect of endogenous estradiol on erythropoietin induction. The anemia, derived from hemodilution, does not act as a drive for erythropoietin induction, but iron deficiency, often observed during pregnancy, might. In order to demonstrate this, we investigated the effects of iron deficiency on estradiol-induced suppression of erythropoietin induction in rats. Single doses of estradiol suppressed hypoxia-, cobalt-, and bleeding-stimulated elevation of plasma erythropoietin levels and renal erythropoietin mRNA expression. Repeated administration of estradiol at 0.1 and 1 mg/kg for 2 months induced a slight anemic trend without elevation of plasma erythropoietin. Feeding an iron-deficient diet for 2 months induced plasma erythropoietin elevation without obvious anemia, but the simultaneous repeated administration of estradiol suppressed it and reversed the iron deficiency. Plasma erythropoietin levels had distinct negative correlations with plasma iron, plasma ferritin, and iron concentrations in the organs, but not with plasma hemoglobin level. These results suggest that iron deficiency would significantly stimulate erythropoietin induction during pregnancy, although estradiol might suppress it through iron restoration. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. F. Gonzales, M. Gasco, V. Tapia, and C. Gonzales-Castaneda High serum testosterone levels are associated with excessive erythrocytosis of chronic mountain sickness in men Am J Physiol Endocrinol Metab, June 1, 2009; 296(6): E1319 - E1325. [Abstract] [Full Text] [PDF] Y. Naito, T. Tsujino, M. Matsumoto, T. Sakoda, M. Ohyanagi, and T. Masuyama Adaptive response of the heart to long-term anemia induced by iron deficiency Am J Physiol Heart Circ Physiol, March 1, 2009; 296(3): H585 - H593. [Abstract] [Full Text] [PDF] F. Giofre, C. Pugliese, G. Alati, A. Messina, and D. Tramontana Three successive pregnancies in a patient with chronic renal disease progressing from chronic renal dysfunction through to institution of dialysis during pregnancy and then on to maintenance dialysis Nephrol. Dial. Transplant., April 1, 2007; 22(4): 1236 - 1240. [Full Text] [PDF]

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