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 Blood, 1 March 2005, Vol. 105, No. 5, pp. 2138-2140.
Prepublished online as a Blood First Edition Paper on October 19, 2004; DOI 10.1182/blood-2004-06-2375.

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Submitted July 2, 2004
Accepted September 30, 2004

High telomerase activity in granulocytes from clonal Polycythemia Vera and Essential Thrombocythemia

Anna M Ferraris*, Rosa Mangerini, Natalija Pujic, Omar Racchi, Davide Rapezzi, Andrea Gallamini, Salvatore Casciaro, and Gian F Gaetani

Ematologia Oncologica, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy; Dipartimento di Medicina Interna, University of Genova, Genova, Italy
Struttura Complessa di Ematologia, Azienda Ospedaliera Santa Croce e Carle, Cuneo, Italy
Dipartimento di Medicina Interna, University of Genova, Genova, Italy

* Corresponding author; email: annamaria.ferraris{at}istge.it.

Essential Thrombocythemia (ET) and Polycythemia Vera (PV) are chronic myeloproliferative disorders which share the involvement of a multipotent progenitor cell and dominance of the transformed clone over normal hematopoiesis. On the other hand, the heterogeneity of these diseases with respect to clonal development from a common progenitor has been well established. In order to identify useful prognostic indicators, we analysed telomerase activity (TA), a known marker of neoplastic proliferation, in granulocytes (PMN) and mononuclear cells (MNC) from 22 female patients with ET and PV. Clonality status was determined by investigation of X chromosome inactivation patterns (XCIPs). We found a statistically significant positive correlation between high TA and monoclonal pattern of XCIP. Therefore our data suggest that the use of multiple tumor markers may contribute to a better understanding of the deregulated physiology of these disorders and provide useful prognostic factors.


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