SEARCH:   Advanced

Blood, 15 February 2005, Vol. 105, No. 4, pp. 1408-1416. Prepublished online as a Blood First Edition Paper on October 14, 2004; DOI 10.1182/blood-2004-06-2385. This Article Full Text (PDF) All Versions of this Article: 2004-06-2385v1 105/4/1408    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Oh, H. Articles by Barrett, A J Search for Related Content PubMed PubMed Citation Articles by Oh, H. Articles by Barrett, A J Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 6, 2004 Accepted October 4, 2004 Comparison of graft-vs-host-disease and survival after HLA-identical sibling bone marrow transplantation in different ethnic populations Hakumei Oh*, Fausto R Loberiza Jr., Mei-Jie Zhang, Olle Ringden, Hideki Akiyama, Takayoshi Asai, Shuichi Miyawaki, Shinichiro Okamoto, Mary M Horowitz, Joseph H Antin, Asad Bashey, Jennifer M Bird, Matthew H Carabasi, Joseph W Fay, Robert P Gale, Roger H Giller, John M Goldman, Gregory A Hale, Richard E Harris, Jean Henslee-Downey, Hans-Jochem Kolb, Mark R Litzow, Philip L McCarthy, Steven M Neudorf, Derek S Serna, Gerard Socie, Peter Tiberghien, and A J Barrett INOUE Memorial Hospital, Chiba, Japan GVHD/Immune Reconstitution Working Committee of the International Bone Marrow Transplant Registry (IBMTR), Health Policy Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, USA Huddinge University Hospital, Huddinge, Sweden Japan Adult Leukemia Study Group, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan Chiba University Hospital, Chiba, Japan Saiseikai Maebashi Hospital, Maebashi, Japan Keio University School of Medicine, Tokyo, Japan Dana-Farber Cancer Institute, Boston, Massachusetts, USA University of California-San Diego, La Jolla, California, USA Southmead Hospital, Clifton, Bristol, United Kingdom University of Southern California/Norris Cancer Center, Los Angeles, California, USA Baylor University Medical Center, Dallas, Texas, USA Center for Advanced Studies in Leukemia, Los Angeles, California, USA The Children's Hospital-Denver, Denver, Colorado, USA Hammersmith Hospital, London, United Kingdom St. Jude Children's Research Hospital, Memphis, Tennessee, USA Children's Hospital Medical Center, Cincinnati, Ohio, USA National Heart, Lung and Blood Institute, National Institute of Health, Bethesda, Maryland, USA University of Munich, Munich, Germany Mayo Clinic Rochester, Rochester, Minnesota, USA Roswell Park Cancer Institute, Buffalo, New York, USA Children's Hospital of Orange County, Orange, California, USA Hospital Saint Louis, Paris, Cedex, France Inserm U645 Etablissement Francais du Sang, Besancon, France * Corresponding author; email: hakumei{at}chive.ocn.ne.jp. The association between ethnicity and the incidence of graft-versus-host disease (GVHD) and other clinical outcomes is controversial. We compared results of HLA-identical sibling bone marrow transplants for leukemia among different ethnic populations, including 562 Japanese, 829 Caucasian Americans, 71 African Americans, 195 Scandinavians and 95 Irish, performed between 1990 and 1999. Results in adults and children were analyzed separately. Multivariate analyses of adult patients showed that Caucasian, African Americans and Irish had significantly higher risks of acute GVHD than Japanese or Scandinavians (relative risk [RR] 1.77, p<0.0001, RR 1.84, p<0.006, RR 2.22, p<0.001, respectively). Caucasian Americans, African Americans and Irish, but not Scandinavian patients had a significantly higher risk of early (1st 3 months after transplant) transplant-related mortality (TRM) compared with Japanese (RR 2.99, p<0.0001, RR 5.88, p<0.0001, RR 2.66, p<0.009, respectively). No differences in the risk of chronic GVHD, relapse, and overall survival were noted. In the pediatric cohort (limited to Japanese and Caucasian Americans), Caucasian Americans had a significantly higher risk of acute (RR 1.93, p=0.04) and chronic (RR 3.16, p=0.002) GVHD. No differences in other clinical outcomes were noted. Our findings suggest that ethnicity may influence the risk of GVHD, although overall survival after transplantation remains similar. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Major minors only? Nelson J. Chao Blood 2005 105: 1377-1378. [Full Text] [PDF] This article has been cited by other articles: X. Y. Han Epidemiologic Analysis of Reactivated Cytomegalovirus Antigenemia in Patients with Cancer J. Clin. Microbiol., April 1, 2007; 45(4): 1126 - 1132. [Abstract] [Full Text] [PDF] S. Takahashi, J. Ooi, A. Tomonari, T. Konuma, N. Tsukada, M. Oiwa-Monna, K. Fukuno, M. Uchiyama, K. Takasugi, T. Iseki, et al. Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors in adult patients with hematologic malignancies after myeloablative conditioning regimen Blood, February 1, 2007; 109(3): 1322 - 1330. [Abstract] [Full Text] [PDF] M.-T. Lin, B. Storer, P. J. Martin, L.-H. Tseng, B. Grogan, P.-J. Chen, L. P. Zhao, and J. A. Hansen Genetic variation in the IL-10 pathway modulates severity of acute graft-versus-host disease following hematopoietic cell transplantation: synergism between IL-10 genotype of patient and IL-10 receptor {beta} genotype of donor Blood, December 1, 2005; 106(12): 3995 - 4001. [Abstract] [Full Text] [PDF]

	Copyright © 2004 by American Society of Hematology         Online ISSN: 1528-0020