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Blood, 15 December 2004, Vol. 104, No. 13, pp. 4308-4310. Prepublished online as a Blood First Edition Paper on August 17, 2004; DOI 10.1182/blood-2004-06-2422. This Article Full Text (PDF) All Versions of this Article: 2004-06-2422v1 104/13/4308    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Krijt, J. Articles by Necas, E. Search for Related Content PubMed PubMed Citation Articles by Krijt, J. Articles by Necas, E. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 28, 2004 Accepted August 1, 2004 Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin Jan Krijt*, Martin Vokurka, Ko-Tung Chang, and Emanuel Necas Institute of Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic * Corresponding author; email: jkri{at}lf1.cuni.cz. Mutations of hepcidin (HAMP) and hemojuvelin (HJV) genes have been recently demonstrated to result in juvenile hemochromatosis. Expression of HAMP is regulated by iron status or infection, whereas regulation of HJV is yet unknown. Using quantitative real-time PCR, we compared expression of Hamp and Rgmc (the murine ortholog of HJV) in livers of mice treated with iron, erythropoietin or lipopolysaccharide, as well as during fetal and postnatal development. Iron overload increased Hamp expression without effect on Rgmc mRNA. Erythropoietin decreased Hamp mRNA, but Rgmc expression was unchanged. Hamp mRNA level decreased after birth by four orders of magnitude, without significant changes in Rgmc expression. Administration of LPS elevated Hamp mRNA levels, while markedly decreasing hepatic Rgmc mRNA levels (to ~ 5 % after 6 hours). The responses of Hamp and Rgmc were quite different and suggested that human HJV expression could be modulated by inflammation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Huang, M. Constante, A. Layoun, and M. M. Santos Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli Blood, April 9, 2009; 113(15): 3593 - 3599. [Abstract] [Full Text] [PDF] S. Pelucchi, R. Mariani, P. Trombini, S. Coletti, M. Pozzi, V. Paolini, D. Barisani, and A. 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