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Blood, 1 April 2005, Vol. 105, No. 7, pp. 2887-2890. Prepublished online as a Blood First Edition Paper on December 14, 2004; DOI 10.1182/blood-2004-06-2423. This Article Full Text (PDF) All Versions of this Article: 2004-06-2423v1 105/7/2887    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Holm, A. M Articles by Froland, S. S Search for Related Content PubMed PubMed Citation Articles by Holm, A. M Articles by Froland, S. S Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 28, 2004 Accepted November 30, 2004 Abnormal interleukin-7 function in common variable immunodeficiency Are M Holm*, Pal Aukrust, Jan K Damas, Fredrik Muller, Bente Halvorsen, and Stig S Froland Section of Clinical Immunology and Infectious Diseases, Medical Department, Rikshospitalet/The National Hospital, Oslo, Norway Section of Clinical Immunology and Infectious Diseases, Medical Department, Rikshospitalet/The National Hospital, Oslo, Norway; Research Institute for Internal Medicine, Rikshospitalet/The National Hospital, Oslo, Norway Research Institute for Internal Medicine, Rikshospitalet/The National Hospital, Oslo, Norway Research Institute for Internal Medicine, Rikshospitalet/The National Hospital, Oslo, Norway; Department of Microbiology, Rikshospitalet/The National Hospital, Oslo, Norway * Corresponding author; email: a.m.holm{at}medisin.uio.no. Common Variable Immunodeficiency is characterized by low levels of circulating immunoglobulins, leading to frequent infections, particularly of the respiratory tract. Frequently, T cell abnormalities are observed. Interleukin-7 (IL-7) is involved in the homeostasis of lymphocytes, and may be elevated in lymphopenia. Mutations of genes related to IL-7 may lead to severe immunodeficiency disorders. We report elevated plasma levels of circulating IL-7 in a subgroup of CVID. These patients have increased numbers of circulating CD8+ T cells with decreased apoptosis and a predominance of CCR7- effector-memory T cells. Moreover, in some of these patients there is impaired response to IL-7 as assessed by in vitro proliferation and secretion of interferon and transforming growth factor . These findings suggest novel pathogenic mechanisms and specific targets for further research in CVID. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: N. Rezaei, A. Aghamohammadi, S. D. Siadat, M. Moin, Z. Pourpak, M. Nejati, H. Ahmadi, S. Kamali, D. Norouzian, B. Tabaraei, et al. Serum Bactericidal Antibody Responses to Meningococcal Polysaccharide Vaccination as a Basis for Clinical Classification of Common Variable Immunodeficiency Clin. Vaccine Immunol., April 1, 2008; 15(4): 607 - 611. [Abstract] [Full Text] [PDF] A. Malaspina, S. Moir, D. G. Chaitt, C. A. Rehm, S. Kottilil, J. Falloon, and A. S. Fauci Idiopathic CD4+ T lymphocytopenia is associated with increases in immature/transitional B cells and serum levels of IL-7 Blood, March 1, 2007; 109(5): 2086 - 2088. [Abstract] [Full Text] [PDF] J. Ho, S. Moir, A. Malaspina, M. L. Howell, W. Wang, A. C. DiPoto, M. A. O'Shea, G. A. Roby, R. Kwan, J. M. Mican, et al. Two overrepresented B cell populations in HIV-infected individuals undergo apoptosis by different mechanisms PNAS, December 19, 2006; 103(51): 19436 - 19441. [Abstract] [Full Text] [PDF] S. E. Johnson, N. Shah, A. Panoskaltsis-Mortari, and T. W. LeBien Murine and Human IL-7 Activate STAT5 and Induce Proliferation of Normal Human Pro-B Cells J. Immunol., December 1, 2005; 175(11): 7325 - 7331. [Abstract] [Full Text] [PDF]

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