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Blood, 1 April 2005, Vol. 105, No. 7, pp. 2631-2639. Prepublished online as a Blood First Edition Paper on December 7, 2004; DOI 10.1182/blood-2004-06-2480. This Article Full Text (PDF) All Versions of this Article: 2004-06-2480v1 105/7/2631    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Taichman, R. S Search for Related Content PubMed PubMed Citation Articles by Taichman, R. S Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 30, 2004 Accepted November 17, 2004 Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem cell niche Russell S Taichman* Periodontics, Prevention and Geriatrics, University of Michigan School of Dentistry, Ann Arbor, MI, USA * Corresponding author; email: rtaich{at}umich.edu. The mechanisms of bone and blood formation have traditionally been viewed as distinct, unrelated processes, but there is compelling evidence to suggest that they are intertwined. Based upon observations that hematopoietic precursors reside in close proximity to endosteal surfaces, we and others hypothesized that osteoblasts play a central role in hematopoiesis, and have shown that osteoblasts produce many factors essential for the survival, renewal and maturation of hematopoietic stem cells (HSCs). Forwarding these observations are studies that demonstrate that disruption or perturbation of normal osteoblastic function has a profound and central role in defining the operational structure of the HSC niche. These observations provide a glimpse of the dimensions and ramifications of HSC-osteoblast interactions. While more research is required to secure a broader grasp of the molecular mechanisms that govern blood and bone biology, the central role for osteoblasts in hematopoietic stem cell regulation is reviewed herein from the perspectives of (i) historical context, (ii) osteoblasts role in supporting stem cell survival, proliferation and/or maintenance, (iii) determining whether osteoblasts participate in the creation of a stem cell niche, (iv) what molecules mediate HSC:osteoblastic interactions, (v) the role of osteoblasts in stem cell transplantation, and (vi) possible future directions for investigation. 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